[22] Clemson 38-3 South Carolina [120] 2019-09-16 07:00
Stadium: Williams-Brice Stadium Round: 1
Home Manager: Dabo Swinney Away Manager: Will Muschamp
Head to Head
| NCAAF | 2018/11/25 00:00 | South Carolina v Clemson | W | 35-56 |
| NCAAF | 2017/11/26 00:30 | Clemson v South Carolina | W | 34-10 |
| NCAAF | 2016/11/27 00:30 | South Carolina v Clemson | W | 7-56 |
| NCAAF | 2015/11/28 17:00 | South Carolina v Clemson | W | 32-37 |
| NCAAF | 2014/11/29 17:00 | Clemson v South Carolina | W | 35-17 |
| NCAAF | 2012/11/24 12:00 | Clemson v South Carolina | L | 17-27 |
| NCAAF | 2011/11/26 12:00 | South Carolina v Clemson | L | 34-13 |
| NCAAF | 2010/11/27 12:00 | Clemson v South Carolina | L | 7-29 |
Home History
| NCAAF | 2019/09/14 23:30 | Clemson v Syracuse | W | 41-6 |
| NCAAF | 2019/09/07 19:30 | Texas A&M v Clemson | W | 10-24 |
| NCAAF | 2019/08/30 00:00 | Georgia Tech v Clemson | W | 14-52 |
| NCAAF | 2019/01/08 01:00 | Clemson v Alabama | W | 44-16 |
| NCAAF | 2018/12/29 21:00 | Notre Dame v Clemson | W | 3-30 |
| NCAAF | 2018/12/02 01:00 | Pittsburgh v Clemson | W | 10-42 |
| NCAAF | 2018/11/25 00:00 | South Carolina v Clemson | W | 35-56 |
| NCAAF | 2018/11/18 00:00 | Duke v Clemson | W | 6-35 |
Away History
| NCAAF | 2019/09/14 19:30 | Alabama v South Carolina | L | 47-23 |
| NCAAF | 2019/09/07 16:00 | Charleston Southern v South Carolina | W | 10-72 |
| NCAAF | 2019/08/31 19:30 | South Carolina v North Carolina | L | 20-24 |
| NCAAF | 2018/12/29 17:00 | South Carolina v Virginia | L | 0-28 |
| NCAAF | 2018/12/01 17:00 | Akron v South Carolina | W | 3-28 |
| NCAAF | 2018/11/25 00:00 | South Carolina v Clemson | L | 35-56 |
| NCAAF | 2018/11/18 00:30 | Tennessee Chattanooga v South Carolina | W | 9-49 |
| NCAAF | 2018/11/10 17:00 | South Carolina v Florida | L | 31-35 |