Stadium: Corwin Stadium at Andrus Field Round: 1
| NCAAF | 2018/11/10 17:00 | Wesleyan Cardinals v Trinity Bantams | L | 0-9 |
| NCAAF | 2018/11/03 17:00 | Williams Ephs v Wesleyan Cardinals | W | 14-21 |
| NCAAF | 2018/10/27 16:30 | Wesleyan Cardinals v Bowdoin Polar Bears | W | 24-0 |
| NCAAF | 2018/10/20 17:00 | Wesleyan Cardinals v Amherst Mammoths | L | 3-33 |
| NCAAF | 2018/10/13 17:00 | Bates Bobcats v Wesleyan Cardinals | W | 13-44 |
| NCAAF | 2018/10/06 17:00 | Colby Mules v Wesleyan Cardinals | W | 20-28 |
| NCAAF | 2018/09/29 17:00 | Wesleyan Cardinals v Hamilton Continentals | L | 29-33 |
| NCAAF | 2018/09/22 22:00 | Tufts Jumbos v Wesleyan Cardinals | L | 16-13 |
| NCAAF | 2018/11/10 18:00 | Colby Mules v Bowdoin Polar Bears | W | 30-14 |
| NCAAF | 2018/11/03 17:00 | Tufts Jumbos v Colby Mules | L | 48-0 |
| NCAAF | 2018/10/27 17:00 | Bates Bobcats v Colby Mules | W | 6-21 |
| NCAAF | 2018/10/20 17:00 | Colby Mules v Hamilton Continentals | W | 23-21 |
| NCAAF | 2018/10/13 17:00 | Amherst Mammoths v Colby Mules | L | 35-9 |
| NCAAF | 2018/10/06 17:00 | Colby Mules v Wesleyan Cardinals | L | 20-28 |
| NCAAF | 2018/09/29 17:00 | Colby Mules v Middlebury Panthers | L | 14-31 |
| NCAAF | 2018/09/22 17:00 | Williams Ephs v Colby Mules | L | 36-14 |