[3] El Zamalek 0-1 Esperance de Tunis [1] 2021-02-22 07:00
Stadium: Cairo International Stadium Round: 4
Head to Head
| CAF Champions League | 2020/03/06 19:00 | Esperance de Tunis v El Zamalek | L | 1-0 |
| CAF Champions League | 2020/02/28 16:00 | El Zamalek v Esperance de Tunis | W | 3-1 |
| CAF Super Cup | 2020/02/14 16:00 | Esperance de Tunis v El Zamalek | W | 1-3 |
Home History
| Egypt Division 1 | 2021/02/17 17:30 | El Zamalek v Ismaily SC | W | 2-1 |
| CAF Champions League | 2021/02/12 19:00 | El Zamalek v MC Alger | D | 0-0 |
| Egypt Division 1 | 2021/02/07 17:30 | El Zamalek v Al Ittihad Al Sakandary | W | 2-0 |
| Egypt Division 1 | 2021/02/02 15:00 | Ghazl El Mahallah v El Zamalek | L | 2-1 |
| Egypt Division 1 | 2021/01/28 17:30 | El Zamalek v Misr Lel Makasa | W | 4-1 |
| Egypt Division 1 | 2021/01/23 15:00 | Aswan FC v El Zamalek | D | 0-0 |
| Egypt Division 1 | 2021/01/19 15:00 | El Zamalek v El Gounah | W | 1-0 |
| Egypt Division 1 | 2021/01/12 15:00 | El Masry v El Zamalek | W | 0-1 |
Away History
| Tunisia League 1 | 2021/02/17 13:00 | JS Kairouanaise v Esperance de Tunis | W | 0-3 |
| CAF Champions League | 2021/02/13 13:00 | Esperance de Tunis v Teungueth FC | W | 2-1 |
| Tunisia League 1 | 2021/02/07 12:00 | ES Metlaoui v Esperance de Tunis | W | 1-2 |
| Tunisia League 1 | 2021/02/03 14:00 | Esperance de Tunis v Bizertin | W | 1-0 |
| Tunisia League 1 | 2021/01/31 15:00 | Esperance de Tunis v Club Africain | W | 1-0 |
| Tunisia League 1 | 2021/01/26 13:00 | Olympique de Beja v Esperance de Tunis | W | 1-4 |
| Tunisia League 1 | 2021/01/23 14:00 | Esperance de Tunis v Stade Tunisien | W | 2-1 |
| Tunisia League 1 | 2021/01/13 13:00 | CS Sfaxien v Esperance de Tunis | L | 2-0 |