[2] Velez Sarsfield 1-0 Barcelona Guayaquil [1] 2021-05-18 10:15
Stadium: Jose Amalfitani Round: 4
Referee: Raphael Claus Home Manager: Mauricio Pellegrino Away Manager: Fabian Bustos
Home History
| Argentina Copa de la Liga Profesional | 2021/05/16 15:00 | Velez Sarsfield v Racing Club | L | 2-4 |
| Copa Libertadores | 2021/05/13 22:00 | Velez Sarsfield v LDU Quito | W | 3-1 |
| Argentina Copa de la Liga Profesional | 2021/05/08 18:30 | Gimnasia LP v Velez Sarsfield | W | 0-5 |
| Copa Libertadores | 2021/05/04 22:15 | Union La Calera v Velez Sarsfield | W | 0-2 |
| Argentina Copa de la Liga Profesional | 2021/04/30 21:00 | Velez Sarsfield v Patronato Parana | W | 1-0 |
| Copa Libertadores | 2021/04/27 22:15 | LDU Quito v Velez Sarsfield | L | 3-1 |
| Argentina Copa de la Liga Profesional | 2021/04/25 14:00 | Lanus v Velez Sarsfield | W | 1-2 |
| Copa Libertadores | 2021/04/21 00:30 | Velez Sarsfield v Flamengo | L | 2-3 |
Away History
| Ecuador LigaPro Serie A | 2021/05/17 00:00 | Club 9 de Octubre v Barcelona Guayaquil | W | 0-1 |
| Copa Libertadores | 2021/05/11 22:15 | The Strongest v Barcelona Guayaquil | L | 2-0 |
| Copa Libertadores | 2021/05/05 00:30 | Barcelona Guayaquil v Boca Juniors | W | 1-0 |
| Ecuador LigaPro Serie A | 2021/05/02 01:30 | Barcelona Guayaquil v Delfin SC | W | 2-1 |
| Copa Libertadores | 2021/04/29 02:00 | Barcelona Guayaquil v The Strongest | W | 4-0 |
| Copa Libertadores | 2021/04/20 22:15 | Santos v Barcelona Guayaquil | W | 0-2 |
| Ecuador LigaPro Serie A | 2021/04/17 00:00 | Mushuc Runa v Barcelona Guayaquil | D | 2-2 |
| Ecuador LigaPro Serie A | 2021/04/08 22:00 | Deportivo Cuenca v Barcelona Guayaquil | L | 1-0 |