[8] Portsmouth 1-2 Milton Keynes Dons [5] 2021-11-18 07:00
Stadium: Fratton Park Round: 28
Referee: Scott Oldham Home Manager: Danny Cowley Away Manager: Liam Manning
Head to Head
| England League 1 | 2021/09/11 14:00 | Milton Keynes Dons v Portsmouth | L | 1-0 |
| England League 1 | 2021/04/17 11:30 | Milton Keynes Dons v Portsmouth | L | 1-0 |
| England League 1 | 2020/10/10 14:00 | Portsmouth v Milton Keynes Dons | W | 2-1 |
| England League 1 | 2020/02/25 19:45 | Portsmouth v Milton Keynes Dons | W | 3-1 |
| England League 1 | 2019/12/29 15:00 | Milton Keynes Dons v Portsmouth | L | 3-1 |
| England League 1 | 2018/02/10 15:00 | Milton Keynes Dons v Portsmouth | W | 1-2 |
| England League 1 | 2017/10/14 14:00 | Portsmouth v Milton Keynes Dons | W | 2-0 |
Home History
| England League 1 | 2021/11/13 15:00 | Wycombe v Portsmouth | W | 0-1 |
| England EFL Trophy | 2021/11/09 19:45 | Portsmouth v Crystal Palace U21 | W | 3-0 |
| England FA Cup | 2021/11/06 15:00 | Portsmouth v Harrow Borough | W | 1-0 |
| England League 1 | 2021/11/02 19:45 | Portsmouth v Cheltenham | D | 1-1 |
| England League 1 | 2021/10/30 14:00 | Portsmouth v Bolton | W | 1-0 |
| England League 1 | 2021/10/23 14:00 | Accrington Stanley v Portsmouth | D | 2-2 |
| England League 1 | 2021/10/19 18:45 | Portsmouth v Ipswich | L | 0-4 |
| England League 1 | 2021/10/16 14:00 | Rotherham v Portsmouth | L | 4-1 |
Away History
| England FA Cup | 2021/11/16 19:45 | Stevenage v Milton Keynes Dons | D | 1-1 |
| England League 1 | 2021/11/13 15:00 | Milton Keynes Dons v Cambridge Utd | W | 4-1 |
| England FA Cup | 2021/11/06 15:00 | Milton Keynes Dons v Stevenage | D | 2-2 |
| England League 1 | 2021/10/30 14:00 | Crewe v Milton Keynes Dons | W | 1-4 |
| England EFL Trophy | 2021/10/26 18:00 | Milton Keynes Dons v Aston Villa U21 | L | 2-4 |
| England League 1 | 2021/10/23 14:00 | Milton Keynes Dons v Rotherham | L | 0-3 |
| England League 1 | 2021/10/19 18:45 | Wigan v Milton Keynes Dons | W | 1-2 |
| England League 1 | 2021/10/16 14:00 | Shrewsbury v Milton Keynes Dons | L | 1-0 |