[12] Tigres UANL 1-1 Santos Laguna [5] 2021-04-03 20:00
Stadium: Estadio Universitario (UANL) Round: 3
Referee: Marco Antonio Ortiz Nava Home Manager: Miguel Herrera Away Manager: Guillermo Almada
Head to Head
| Mexico Liga MX | 2021/01/18 01:06 | Santos Laguna v Tigres UANL | L | 2-0 |
| Mexico Liga MX | 2020/09/13 00:00 | Tigres UANL v Santos Laguna | W | 2-0 |
| Mexico Liga MX | 2020/02/17 00:45 | Santos Laguna v Tigres UANL | L | 2-1 |
| Mexico Liga MX | 2019/10/06 00:00 | Tigres UANL v Santos Laguna | W | 4-0 |
| CONCACAF Champions Cup | 2019/04/11 00:00 | Santos Laguna v Tigres UANL | L | 3-2 |
| CONCACAF Champions Cup | 2019/04/04 02:00 | Tigres UANL v Santos Laguna | W | 3-0 |
| Mexico Liga MX | 2019/02/03 01:00 | Tigres UANL v Santos Laguna | W | 2-1 |
| Mexico Liga MX | 2018/08/19 23:00 | Santos Laguna v Tigres UANL | L | 3-1 |
Home History
| Mexico Liga MX | 2021/03/19 02:00 | Pachuca v Tigres UANL | L | 1-0 |
| Mexico Liga MX | 2021/03/14 01:00 | Tigres UANL v Mazatlan FC | L | 1-2 |
| Mexico Liga MX | 2021/03/06 03:30 | Puebla v Tigres UANL | D | 1-1 |
| Mexico Liga MX | 2021/03/03 01:00 | Tigres UANL v Toluca | L | 0-1 |
| Mexico Liga MX | 2021/02/26 03:00 | Atletico San Luis v Tigres UANL | D | 2-2 |
| Mexico Liga MX | 2021/02/22 01:00 | Tigres UANL v Tijuana | W | 3-2 |
| Mexico Liga MX | 2021/02/18 03:00 | Tigres UANL v Cruz Azul | L | 0-2 |
| FIFA Club World Cup | 2021/02/11 18:00 | Bayern Munich v Tigres UANL | L | 1-0 |
Away History
| Mexico Liga MX | 2021/03/22 01:06 | Santos Laguna v Leon | L | 1-2 |
| Mexico Liga MX | 2021/03/14 03:05 | Tijuana v Santos Laguna | W | 0-1 |
| Mexico Liga MX | 2021/03/08 01:06 | Santos Laguna v Necaxa | W | 3-1 |
| Mexico Liga MX | 2021/03/05 03:00 | Unam Pumas v Santos Laguna | L | 1-0 |
| Mexico Liga MX | 2021/03/01 01:06 | Santos Laguna v Juarez FC | W | 3-2 |
| Mexico Liga MX | 2021/02/19 03:00 | Atletico San Luis v Santos Laguna | L | 1-0 |
| Mexico Liga MX | 2021/02/15 01:06 | Santos Laguna v Monterrey | W | 1-0 |
| Mexico Liga MX | 2021/02/06 23:00 | Atlas v Santos Laguna | D | 1-1 |