[15] Michigan 21-17 Penn State [31] 2021-09-21 09:00
Stadium: West Shore Home Field at Beaver Stadium Round: 1
Home Manager: Jim Harbaugh Away Manager: James Franklin
Head to Head
| NCAAF | 2020/11/28 17:00 | Penn State v Michigan | L | 27-17 |
| NCAAF | 2019/10/19 23:30 | Michigan v Penn State | L | 21-28 |
| NCAAF | 2018/11/03 19:45 | Penn State v Michigan | W | 7-42 |
| NCAAF | 2017/10/21 23:30 | Michigan v Penn State | L | 13-42 |
| NCAAF | 2016/09/24 19:30 | Penn State v Michigan | W | 10-49 |
| NCAAF | 2015/11/21 17:00 | Penn State v Michigan | W | 16-28 |
| NCAAF | 2014/10/11 23:00 | Michigan v Penn State | W | 18-13 |
| NCAAF | 2010/10/30 12:00 | Penn State v Michigan | L | 41-31 |
Home History
| NCAAF | 2021/09/18 16:00 | Northern Illinois v Michigan | W | 10-63 |
| NCAAF | 2021/09/12 00:00 | Washington v Michigan | W | 10-31 |
| NCAAF | 2021/09/04 16:00 | Western Michigan v Michigan | W | 14-47 |
| NCAAF | 2020/11/28 17:00 | Penn State v Michigan | L | 27-17 |
| NCAAF | 2020/11/22 00:30 | Michigan v Rutgers | W | 48-42 |
| NCAAF | 2020/11/15 00:30 | Wisconsin v Michigan | L | 49-11 |
| NCAAF | 2020/11/07 17:00 | Michigan v Indiana | L | 21-38 |
| NCAAF | 2020/10/31 16:00 | Michigan State v Michigan | L | 27-24 |
Away History
| NCAAF | 2021/09/18 23:30 | Auburn v Penn State | W | 20-28 |
| NCAAF | 2021/09/11 19:30 | Ball State v Penn State | W | 13-44 |
| NCAAF | 2021/09/04 16:00 | Penn State v Wisconsin | W | 16-10 |
| NCAAF | 2020/12/19 22:30 | Illinois v Penn State | W | 21-56 |
| NCAAF | 2020/12/12 17:00 | Michigan State v Penn State | W | 24-39 |
| NCAAF | 2020/12/05 17:00 | Penn State v Rutgers | W | 23-7 |
| NCAAF | 2020/11/28 17:00 | Penn State v Michigan | W | 27-17 |
| NCAAF | 2020/11/21 20:30 | Iowa v Penn State | L | 41-21 |