[55] Eastern Michigan 52-49 Toledo [74] 2021-09-24 19:30
Stadium: The Glass Bowl Round: 1
Home Manager: Jason Candle Away Manager: Chris Creighton
Head to Head
| NCAAF | 2020/11/19 00:00 | Toledo v Eastern Michigan | L | 45-28 |
| NCAAF | 2019/10/26 19:30 | Eastern Michigan v Toledo | L | 34-37 |
| NCAAF | 2018/10/13 16:00 | Toledo v Eastern Michigan | W | 26-28 |
| NCAAF | 2017/10/07 16:00 | Eastern Michigan v Toledo | L | 15-20 |
| NCAAF | 2016/10/08 19:00 | Toledo v Eastern Michigan | L | 35-20 |
| NCAAF | 2015/10/17 16:00 | Toledo v Eastern Michigan | L | 63-20 |
| NCAAF | 2014/11/28 18:00 | Eastern Michigan v Toledo | L | 16-52 |
| NCAAF | 2012/10/13 12:00 | Eastern Michigan v Toledo | L | 47-52 |
Home History
| NCAAF | 2021/09/18 19:30 | Eastern Michigan v Massachusetts | W | 42-28 |
| NCAAF | 2021/09/11 23:00 | Eastern Michigan v Wisconsin | L | 7-34 |
| NCAAF | 2021/09/03 23:00 | St.Francis (PA) v Eastern Michigan | W | 15-35 |
| NCAAF | 2020/12/12 17:00 | Northern Illinois v Eastern Michigan | W | 33-41 |
| NCAAF | 2020/12/05 19:00 | Eastern Michigan v Western Michigan | W | 53-42 |
| NCAAF | 2020/11/27 21:00 | Central Michigan v Eastern Michigan | L | 31-23 |
| NCAAF | 2020/11/19 00:00 | Toledo v Eastern Michigan | L | 45-28 |
| NCAAF | 2020/11/12 00:00 | Eastern Michigan v Ball State | L | 31-38 |
Away History
| NCAAF | 2021/09/18 20:00 | Colorado State v Toledo | L | 22-6 |
| NCAAF | 2021/09/11 18:30 | Toledo v Notre Dame | L | 29-32 |
| NCAAF | 2021/09/04 23:00 | Norfolk State v Toledo | W | 10-49 |
| NCAAF | 2020/12/12 20:00 | Central Michigan v Toledo | W | 23-24 |
| NCAAF | 2020/12/05 17:00 | Toledo v Northern Illinois | W | 41-24 |
| NCAAF | 2020/11/28 17:00 | Ball State v Toledo | L | 27-24 |
| NCAAF | 2020/11/19 00:00 | Toledo v Eastern Michigan | W | 45-28 |
| NCAAF | 2020/11/12 01:00 | Toledo v Western Michigan | L | 38-41 |