[10] Wake Forest 27-48 Clemson [35] 2021-08-30 05:00
Stadium: Memorial Stadium Round: 1
Home Manager: Dabo Swinney Away Manager: Dave Clawson
Head to Head
| NCAAF | 2020/09/12 23:30 | Clemson v Wake Forest | L | 37-13 |
| NCAAF | 2019/11/16 20:30 | Wake Forest v Clemson | L | 3-52 |
| NCAAF | 2018/10/06 19:30 | Clemson v Wake Forest | L | 63-3 |
| NCAAF | 2017/10/07 16:00 | Wake Forest v Clemson | L | 14-28 |
| NCAAF | 2016/11/20 00:00 | Clemson v Wake Forest | L | 35-13 |
| NCAAF | 2015/11/21 20:30 | Clemson v Wake Forest | L | 33-13 |
| NCAAF | 2014/11/07 00:30 | Wake Forest v Clemson | L | 20-34 |
| NCAAF | 2012/10/25 12:00 | Wake Forest v Clemson | L | 13-42 |
Home History
| NCAAF | 2020/12/30 17:00 | Wisconsin v Wake Forest | L | 42-28 |
| NCAAF | 2020/12/12 17:00 | Wake Forest v Louisville | L | 21-45 |
| NCAAF | 2020/11/14 17:00 | Wake Forest v North Carolina | L | 53-59 |
| NCAAF | 2020/10/31 16:00 | Wake Forest v Syracuse | W | 38-14 |
| NCAAF | 2020/10/24 19:30 | Virginia Tech v Wake Forest | W | 16-23 |
| NCAAF | 2020/10/17 20:00 | Virginia v Wake Forest | W | 23-40 |
| NCAAF | 2020/10/02 23:00 | Campbell v Wake Forest | W | 14-66 |
| NCAAF | 2020/09/20 00:00 | Wake Forest v NC State | L | 42-45 |
Away History
| NCAAF | 2021/01/02 01:00 | Ohio State v Clemson | L | 49-28 |
| NCAAF | 2020/12/19 21:00 | Clemson v Notre Dame | W | 34-10 |
| NCAAF | 2020/12/06 00:30 | Clemson v Virginia Tech | W | 45-10 |
| NCAAF | 2020/11/28 20:30 | Pittsburgh v Clemson | W | 17-52 |
| NCAAF | 2020/11/08 00:30 | Clemson v Notre Dame | L | 40-47 |
| NCAAF | 2020/10/31 16:00 | Boston College v Clemson | W | 28-34 |
| NCAAF | 2020/10/24 16:00 | Syracuse v Clemson | W | 21-47 |
| NCAAF | 2020/10/17 16:00 | Clemson v Georgia Tech | W | 73-7 |