[11] CLB Blue Jackets 7-4 BUF Sabres [6] 2021-10-14 20:00
Stadium: KeyBank Center
Home Manager: Brad Larsen Away Manager: Don Granato
Head to Head
| NHL Pre-Season | 2021/10/04 23:00 | CLB Blue Jackets v BUF Sabres | W | 5-3 |
| NHL Pre-Season | 2021/09/28 23:00 | BUF Sabres v CLB Blue Jackets | L | 5-4 |
| NHL | 2020/02/14 00:00 | CLB Blue Jackets v BUF Sabres | L | 3-4 |
| NHL | 2020/02/01 18:00 | CLB Blue Jackets v BUF Sabres | L | 1-2 |
| NHL | 2019/10/07 23:00 | BUF Sabres v CLB Blue Jackets | W | 3-4 |
| NHL Pre-Season | 2019/09/25 23:00 | CLB Blue Jackets v BUF Sabres | L | 3-4 |
| NHL Pre-Season | 2019/09/17 23:00 | BUF Sabres v CLB Blue Jackets | W | 1-4 |
| NHL | 2019/03/31 22:00 | CLB Blue Jackets v BUF Sabres | W | 4-0 |
Home History
| NHL Pre-Season | 2021/10/09 23:00 | PIT Penguins v CLB Blue Jackets | L | 4-3 |
| NHL Pre-Season | 2021/10/09 00:00 | CLB Blue Jackets v STL Blues | L | 3-7 |
| NHL Pre-Season | 2021/10/06 23:00 | DET Red Wings v CLB Blue Jackets | W | 2-4 |
| NHL Pre-Season | 2021/10/04 23:00 | CLB Blue Jackets v BUF Sabres | W | 5-3 |
| NHL Pre-Season | 2021/10/02 23:00 | CLB Blue Jackets v DET Red Wings | L | 1-5 |
| NHL Pre-Season | 2021/09/29 23:00 | STL Blues v CLB Blue Jackets | W | 2-5 |
| NHL Pre-Season | 2021/09/28 23:00 | BUF Sabres v CLB Blue Jackets | L | 5-4 |
| NHL Pre-Season | 2021/09/27 23:00 | CLB Blue Jackets v PIT Penguins | W | 3-0 |
Away History
| NHL Pre-Season | 2021/10/09 19:00 | DET Red Wings v BUF Sabres | W | 1-3 |
| NHL Pre-Season | 2021/10/05 23:00 | BUF Sabres v PIT Penguins | L | 4-5 |
| NHL Pre-Season | 2021/10/04 23:00 | CLB Blue Jackets v BUF Sabres | L | 5-3 |
| NHL Pre-Season | 2021/10/01 23:00 | PIT Penguins v BUF Sabres | L | 2-1 |
| NHL Pre-Season | 2021/09/30 23:30 | BUF Sabres v DET Red Wings | L | 2-6 |
| NHL Pre-Season | 2021/09/28 23:00 | BUF Sabres v CLB Blue Jackets | W | 5-4 |
| NHL | 2021/05/08 19:00 | BUF Sabres v PIT Penguins | L | 0-1 |
| NHL | 2021/05/06 23:00 | BUF Sabres v PIT Penguins | L | 4-8 |