[7] OTT Senators 0-6 TOR Maple Leafs [3] 2021-10-25 16:00
Stadium: Scotiabank Arena
Home Manager: Away Manager: Sheldon Keefe
Head to Head
| NHL | 2021/10/16 23:00 | OTT Senators v TOR Maple Leafs | L | 1-3 |
| NHL | 2021/10/14 23:00 | TOR Maple Leafs v OTT Senators | W | 2-3 |
| NHL Pre-Season | 2021/10/09 23:00 | OTT Senators v TOR Maple Leafs | L | 1-4 |
| NHL Pre-Season | 2021/10/04 23:00 | TOR Maple Leafs v OTT Senators | L | 3-1 |
| NHL Pre-Season | 2021/09/29 23:00 | TOR Maple Leafs v OTT Senators | L | 4-0 |
| NHL | 2021/05/13 00:00 | TOR Maple Leafs v OTT Senators | W | 3-4 |
| NHL | 2021/04/10 23:00 | OTT Senators v TOR Maple Leafs | L | 5-6 |
| NHL | 2021/03/25 23:00 | TOR Maple Leafs v OTT Senators | L | 3-2 |
Home History
| NHL | 2021/10/23 17:00 | NY Rangers v OTT Senators | L | 3-2 |
| NHL | 2021/10/21 23:00 | SJ Sharks v OTT Senators | L | 2-1 |
| NHL | 2021/10/17 21:00 | DAL Stars v OTT Senators | W | 2-3 |
| NHL | 2021/10/16 23:00 | OTT Senators v TOR Maple Leafs | L | 1-3 |
| NHL | 2021/10/14 23:00 | TOR Maple Leafs v OTT Senators | W | 2-3 |
| NHL Pre-Season | 2021/10/09 23:00 | OTT Senators v TOR Maple Leafs | L | 1-4 |
| NHL Pre-Season | 2021/10/07 23:00 | OTT Senators v MTL Canadiens | W | 5-4 |
| NHL Pre-Season | 2021/10/04 23:00 | TOR Maple Leafs v OTT Senators | L | 3-1 |
Away History
| NHL | 2021/10/23 23:00 | TOR Maple Leafs v PIT Penguins | L | 1-7 |
| NHL | 2021/10/22 22:00 | SJ Sharks v TOR Maple Leafs | L | 5-3 |
| NHL | 2021/10/18 23:00 | NY Rangers v TOR Maple Leafs | L | 2-1 |
| NHL | 2021/10/16 23:00 | OTT Senators v TOR Maple Leafs | W | 1-3 |
| NHL | 2021/10/14 23:00 | TOR Maple Leafs v OTT Senators | L | 2-3 |
| NHL | 2021/10/13 23:00 | MTL Canadiens v TOR Maple Leafs | W | 1-2 |
| NHL Pre-Season | 2021/10/09 23:00 | OTT Senators v TOR Maple Leafs | W | 1-4 |
| NHL Pre-Season | 2021/10/05 23:00 | MTL Canadiens v TOR Maple Leafs | W | 2-6 |