Stadium: W.S. Hanner Fieldhouse
Home Manager: Chad Killinger Away Manager: Rick Pietri
| WNCAAB | 2021/11/24 18:00 | Indiana State (W) v Western Kentucky (W) | L | 65-83 |
| WNCAAB | 2021/11/17 23:00 | Eastern Illinois (W) v Indiana State (W) | L | 64-55 |
| WNCAAB | 2021/11/14 19:00 | Indiana State (W) v Saint Louis (W) | L | 58-65 |
| WNCAAB | 2021/11/09 23:00 | Indiana State (W) v Stephens Women | W | 88-33 |
| WNCAAB | 2021/03/11 22:30 | Indiana State (W) v Southern Illinois (W) | L | 89-90 |
| WNCAAB | 2021/03/06 22:00 | Bradley Women v Indiana State (W) | L | 80-58 |
| WNCAAB | 2021/03/06 00:00 | Bradley Women v Indiana State (W) | L | 86-52 |
| WNCAAB | 2021/02/24 23:00 | Evansville (W) v Indiana State (W) | W | 69-85 |
| WNCAAB | 2021/11/21 20:00 | Jacksonville State (W) v Vanderbilt (W) | L | 61-71 |
| WNCAAB | 2021/11/18 00:00 | Jacksonville State (W) v Samford (W) | W | 56-53 |
| WNCAAB | 2021/11/14 18:00 | Jacksonville State (W) v Davidson (W) | L | 58-69 |
| WNCAAB | 2021/11/09 16:30 | Jacksonville State (W) v Auburn Montgomery Women | W | 89-39 |
| WNCAAB | 2021/03/04 19:00 | Tennessee Tech (W) v Jacksonville State (W) | L | 79-64 |
| WNCAAB | 2021/02/27 19:00 | Jacksonville State (W) v Austin Peay (W) | W | 60-44 |
| WNCAAB | 2021/02/25 22:30 | Jacksonville State (W) v Murray State (W) | L | 75-78 |
| WNCAAB | 2021/02/22 19:00 | Jacksonville State (W) v SIU Edwardsville (W) | W | 61-47 |