Stadium: CEFCU Arena
Home Manager: Bryan Mullins Away Manager: Dan Muller
| NCAAB | 2021/02/14 21:00 | Illinois St v Southern Illinois | W | 49-59 |
| NCAAB | 2021/02/13 21:00 | Illinois St v Southern Illinois | L | 80-55 |
| NCAAB | 2020/01/25 20:00 | Southern Illinois v Illinois St | W | 58-55 |
| NCAAB | 2020/01/04 21:00 | Illinois St v Southern Illinois | W | 55-67 |
| NCAAB | 2019/03/02 19:00 | Illinois St v Southern Illinois | W | 63-72 |
| NCAAB | 2019/01/16 00:00 | Southern Illinois v Illinois St | L | 58-59 |
| NCAAB | 2018/03/04 00:10 | Illinois St v Southern Illinois | L | 76-68 |
| NCAAB | 2018/02/09 02:00 | Southern Illinois v Illinois St | L | 68-76 |
| NCAAB | 2021/12/29 01:00 | Grambling State v Southern Illinois | W | 64-75 |
| NCAAB | 2021/12/22 22:00 | Southern Illinois v San Francisco | L | 52-64 |
| NCAAB | 2021/12/18 21:00 | Southern Illinois v Maryville | W | 75-55 |
| NCAAB | 2021/12/16 01:00 | SE Missouri State v Southern Illinois | W | 55-80 |
| NCAAB | 2021/12/11 19:00 | Southern Illinois v Tulsa | L | 65-69 |
| NCAAB | 2021/12/05 02:00 | Southern Miss v Southern Illinois | W | 41-66 |
| NCAAB | 2021/12/02 00:00 | Southern Illinois v Evansville | W | 54-52 |
| NCAAB | 2021/11/27 01:00 | Alcorn State v Southern Illinois | W | 59-62 |
| NCAAB | 2022/01/02 19:00 | Illinois St v Valparaiso | L | 76-81 |
| NCAAB | 2021/12/30 01:00 | Illinois St v Wisconsin | L | 85-89 |
| NCAAB | 2021/12/21 20:00 | Texas San Antonio v Illinois St | W | 64-81 |
| NCAAB | 2021/12/18 21:00 | Ball State v Illinois St | W | 64-85 |
| NCAAB | 2021/12/15 01:00 | Illinois St v Quincy University | W | 81-63 |
| NCAAB | 2021/12/11 20:00 | Illinois St v Chicago St | W | 81-71 |
| NCAAB | 2021/12/04 21:00 | Jackson State v Illinois St | L | 61-55 |
| NCAAB | 2021/12/02 01:00 | Missouri State v Illinois St | W | 74-79 |