Stadium: CEFCU Arena
Home Manager: Bryan Mullins Away Manager: Dan Muller
| NCAAB | 2021/02/14 21:00 | Illinois St v Southern Illinois | W | 49-59 |
| NCAAB | 2021/02/13 21:00 | Illinois St v Southern Illinois | L | 80-55 |
| NCAAB | 2020/01/25 20:00 | Southern Illinois v Illinois St | W | 58-55 |
| NCAAB | 2020/01/04 21:00 | Illinois St v Southern Illinois | W | 55-67 |
| NCAAB | 2019/03/02 19:00 | Illinois St v Southern Illinois | W | 63-72 |
| NCAAB | 2019/01/16 00:00 | Southern Illinois v Illinois St | L | 58-59 |
| NCAAB | 2018/03/04 00:10 | Illinois St v Southern Illinois | L | 76-68 |
| NCAAB | 2018/02/09 02:00 | Southern Illinois v Illinois St | L | 68-76 |
| NCAAB | 2021/11/27 01:00 | Alcorn State v Southern Illinois | W | 59-62 |
| NCAAB | 2021/11/22 22:45 | Creighton v Southern Illinois | L | 66-64 |
| NCAAB | 2021/11/22 01:00 | Northeastern v Southern Illinois | L | 59-47 |
| NCAAB | 2021/11/20 01:00 | Southern Illinois v Colorado | W | 67-63 |
| NCAAB | 2021/11/13 01:00 | Austin Peay v Southern Illinois | W | 55-73 |
| NCAAB | 2021/11/09 23:00 | Southern Illinois v Arkansas LR | L | 66-69 |
| NCAAB | 2021/03/05 17:00 | Southern Illinois v Loyola Chicago | L | 49-73 |
| NCAAB | 2021/03/04 23:00 | Southern Illinois v Bradley | W | 73-63 |
| NCAAB | 2021/11/28 02:00 | Illinois St v Purdue Northwest | W | 81-71 |
| NCAAB | 2021/11/24 23:00 | Buffalo v Illinois St | L | 106-90 |
| NCAAB | 2021/11/24 01:30 | Illinois St v St Louis | L | 76-82 |
| NCAAB | 2021/11/21 00:00 | Bucknell v Illinois St | W | 100-105 |
| NCAAB | 2021/11/17 01:00 | Murray State v Illinois St | L | 77-65 |
| NCAAB | 2021/11/12 23:00 | Illinois St v Eastern Michigan | L | 98-103 |
| NCAAB | 2021/11/10 01:00 | UNC Wilmington v Illinois St | W | 63-68 |
| NCAAB | 2021/03/05 02:08 | Illinois St v Northern Iowa | L | 60-65 |