Stadium: Mitchell Center
Home Manager: Richie Riley Away Manager: Brian Barone
| NCAAB | 2021/03/04 01:00 | SIU Edwardsville v Belmont | L | 61-78 |
| NCAAB | 2021/02/27 23:00 | SE Missouri State v SIU Edwardsville | L | 69-63 |
| NCAAB | 2021/02/25 23:00 | Tennessee Martin v SIU Edwardsville | W | 53-66 |
| NCAAB | 2021/02/22 23:00 | Morehead State v SIU Edwardsville | L | 56-48 |
| NCAAB | 2021/02/21 01:30 | SIU Edwardsville v Murray State | L | 62-89 |
| NCAAB | 2021/02/19 01:30 | SIU Edwardsville v Austin Peay | L | 57-79 |
| NCAAB | 2021/02/15 22:00 | Murray State v SIU Edwardsville | L | 86-57 |
| NCAAB | 2021/02/13 22:00 | SIU Edwardsville v Jacksonville St | L | 60-80 |
| NCAAB | 2021/03/06 23:00 | South Alabama v UL Lafayette | L | 68-79 |
| NCAAB | 2021/03/05 23:30 | UL Monroe v South Alabama | W | 72-80 |
| NCAAB | 2021/02/28 00:00 | Georgia State v South Alabama | L | 82-73 |
| NCAAB | 2021/02/27 02:00 | Georgia State v South Alabama | L | 84-81 |
| NCAAB | 2021/02/20 21:00 | South Alabama v Appalachian State | W | 56-54 |
| NCAAB | 2021/02/19 23:00 | South Alabama v Appalachian State | W | 65-63 |
| NCAAB | 2021/02/13 22:00 | South Alabama v Troy | W | 58-51 |
| NCAAB | 2021/02/12 00:00 | Troy v South Alabama | W | 70-73 |