[14] BUF Sabres 0-5 OTT Senators [15] 2021-12-11 14:00
Stadium: Canadian Tire Centre
Home Manager: Away Manager: Don Granato
Head to Head
| NHL | 2020/02/19 00:30 | BUF Sabres v OTT Senators | L | 4-7 |
| NHL | 2020/01/29 00:00 | OTT Senators v BUF Sabres | L | 5-2 |
| NHL | 2019/12/24 00:30 | BUF Sabres v OTT Senators | L | 1-3 |
| NHL | 2019/11/17 00:00 | OTT Senators v BUF Sabres | W | 2-4 |
| NHL | 2019/04/04 23:00 | OTT Senators v BUF Sabres | W | 2-5 |
| NHL | 2019/03/26 23:30 | BUF Sabres v OTT Senators | L | 0-4 |
| NHL | 2018/11/03 18:00 | OTT Senators v BUF Sabres | W | 2-9 |
| NHL | 2018/11/01 23:30 | BUF Sabres v OTT Senators | L | 2-4 |
Home History
| NHL | 2021/12/11 00:00 | NY Rangers v BUF Sabres | L | 2-1 |
| NHL | 2021/12/08 00:30 | ANA Ducks v BUF Sabres | L | 2-0 |
| NHL | 2021/12/05 00:30 | BUF Sabres v CAR Hurricanes | L | 2-6 |
| NHL | 2021/12/03 00:00 | BUF Sabres v FLA Panthers | L | 4-7 |
| NHL | 2021/11/30 00:00 | SEA Kraken v BUF Sabres | L | 7-4 |
| NHL | 2021/11/28 00:00 | BUF Sabres v DET Red Wings | L | 2-3 |
| NHL | 2021/11/27 00:00 | MTL Canadiens v BUF Sabres | W | 1-4 |
| NHL | 2021/11/25 00:00 | BOS Bruins v BUF Sabres | L | 5-1 |
Away History
| NHL | 2021/12/08 00:00 | NY Islanders v OTT Senators | L | 5-3 |
| NHL | 2021/12/07 00:00 | OTT Senators v NJ Devils | W | 3-2 |
| NHL | 2021/12/05 00:00 | COL Avalanche v OTT Senators | D | 5-5 |
| NHL | 2021/12/03 00:00 | OTT Senators v CAR Hurricanes | W | 3-2 |
| NHL | 2021/12/02 00:30 | VAN Canucks v OTT Senators | L | 6-2 |
| NHL | 2021/11/28 00:00 | OTT Senators v LA Kings | L | 2-4 |
| NHL | 2021/11/26 21:00 | OTT Senators v ANA Ducks | L | 0-4 |
| NHL | 2021/11/25 03:30 | OTT Senators v SJ Sharks | L | 3-6 |