Stadium: Mount Union Stadium Round: 3
| NCAAF | 2021/11/13 18:30 | Marietta Pioneers v Mount Union | W | 7-37 |
| NCAAF | 2021/11/06 17:30 | Mount Union v Muskingum Muskies | W | 73-7 |
| NCAAF | 2021/10/30 18:00 | Mount Union v Ohio Northern Polar Bears | W | 42-35 |
| NCAAF | 2021/10/23 17:30 | Heidelberg Student Princes v Mount Union | W | 14-49 |
| NCAAF | 2021/10/16 17:30 | Mount Union v Capital Crusaders | W | 63-0 |
| NCAAF | 2021/10/09 19:00 | Wilmington Quakers v Mount Union | W | 0-63 |
| NCAAF | 2021/10/02 17:30 | Mount Union v Otterbein Cardinals | W | 55-0 |
| NCAAF | 2021/09/25 17:30 | John Carroll Blue Streaks v Mount Union | W | 14-28 |
| NCAAF | 2021/11/13 17:00 | Muhlenberg Mules v Moravian Greyhounds | W | 55-0 |
| NCAAF | 2021/11/06 17:00 | Susquehanna Crusaders v Muhlenberg Mules | W | 27-52 |
| NCAAF | 2021/10/30 17:00 | Franklin And Marshall Diplomats v Muhlenberg Mules | W | 10-27 |
| NCAAF | 2021/10/23 16:00 | Muhlenberg Mules v Juniata Eagles | W | 56-16 |
| NCAAF | 2021/10/15 23:00 | Muhlenberg Mules v Johns Hopkins Blue Jays | W | 21-6 |
| NCAAF | 2021/10/02 17:00 | Gettysburg Bullets v Muhlenberg Mules | W | 19-54 |
| NCAAF | 2021/09/25 18:00 | Mcdaniel Green Terror v Muhlenberg Mules | W | 0-23 |
| NCAAF | 2021/09/18 17:00 | Muhlenberg Mules v Ursinus Bears | L | 35-42 |