| Colombia Regional League | 2021/09/17 16:00 | Sellos Colombianos v E.D.P IND. Medellin | W | 3-5 |
| Colombia Regional League | 2021/08/21 21:10 | Sol de Oriente v E.D.P IND. Medellin | L | 2-1 |
| Colombia Regional League | 2021/07/02 17:11 | Club Deportivo La Chalaca v E.D.P IND. Medellin | W | 0-2 |
| Colombia Regional League | 2021/06/27 17:15 | E.D.P IND. Medellin v Estudiantes de Medellin | L | 0-1 |
| Colombia Regional League | 2021/03/26 16:19 | Estudiantes de Medellin v E.D.P IND. Medellin | W | 0-1 |
| Colombia Regional League | 2021/03/16 17:51 | E.D.P IND. Medellin v Talento y Vida | W | 5-1 |
| Colombia Regional League | 2021/02/05 20:24 | Inder Girardota v E.D.P IND. Medellin | W | 2-7 |
| Colombia Regional League | 2021/01/25 16:00 | Sol de Oriente v E.D.P IND. Medellin | D | 0-0 |
| Colombia Regional League | 2021/09/22 16:00 | Independiente Sabaneta v Ferrovalvulas FC | W | 1-2 |
| Colombia Regional League | 2021/08/29 15:13 | Ferrovalvulas FC v Sol de Oriente | W | 2-1 |
| Colombia Regional League | 2021/07/24 21:18 | Ferrovalvulas FC v Club Deportivo La Chalaca | W | 3-1 |
| Colombia Regional League | 2021/07/05 19:12 | Estudiantes de Medellin v Ferrovalvulas FC | D | 0-0 |
| Colombia Regional League | 2021/06/13 19:17 | Ferrovalvulas FC v Total Soccer FC | L | 0-1 |
| Colombia Regional League | 2021/03/19 14:00 | Sol de Oriente v Ferrovalvulas FC | W | 0-1 |
| Colombia Regional League | 2021/02/13 15:22 | Ferrovalvulas FC v Ditaires FC | W | 3-1 |
| Colombia Regional League | 2021/01/31 21:00 | Deportivo Alexis Garcia v Ferrovalvulas FC | D | 0-0 |