Head to Head
| England U23 Premier League Cup | 2021/09/02 18:00 | Arsenal U23 v Southampton U23 | D | 1-1 |
| England Premier League 2 | 2021/03/05 14:00 | Southampton U23 v Arsenal U23 | D | 2-2 |
| England Premier League 2 | 2020/09/11 14:00 | Arsenal U23 v Southampton U23 | W | 1-2 |
| England Premier League 2 | 2019/11/23 13:00 | Arsenal U23 v Southampton U23 | L | 1-0 |
| England Premier League 2 | 2017/01/16 19:00 | Southampton U23 v Arsenal U23 | L | 1-3 |
| England Premier League 2 | 2016/10/14 18:00 | Arsenal U23 v Southampton U23 | D | 0-0 |
Home History
| England Premier League 2 | 2021/09/27 12:30 | Birmingham U23 v Southampton U23 | L | 3-2 |
| England U23 Premier League Cup | 2021/09/23 18:00 | Southampton U23 v West Brom U23 | L | 0-6 |
| England Premier League 2 | 2021/09/19 13:00 | Southampton U23 v Burnley U23 | L | 0-2 |
| England Premier League 2 | 2021/09/10 18:00 | Fulham U23 v Southampton U23 | L | 3-0 |
| England U23 Premier League Cup | 2021/09/02 18:00 | Arsenal U23 v Southampton U23 | D | 1-1 |
| England Premier League 2 | 2021/08/29 11:00 | Middlesbrough U23 v Southampton U23 | L | 2-1 |
| England Premier League 2 | 2021/08/23 18:00 | Nottm Forest U23 v Southampton U23 | D | 0-0 |
| England Premier League 2 | 2021/08/15 13:00 | Southampton U23 v Norwich U23 | L | 0-3 |
Away History
| England Premier League 2 | 2021/09/25 14:00 | Man City U23 v Arsenal U23 | D | 2-2 |
| England Premier League 2 | 2021/09/19 11:00 | Chelsea U23 v Arsenal U23 | W | 1-6 |
| England Premier League 2 | 2021/09/11 12:00 | Arsenal U23 v Man Utd U23 | W | 3-1 |
| England U23 Premier League Cup | 2021/09/02 18:00 | Arsenal U23 v Southampton U23 | D | 1-1 |
| England Premier League 2 | 2021/08/27 11:00 | Tottenham U23 v Arsenal U23 | W | 1-2 |
| England Premier League 2 | 2021/08/20 18:00 | Arsenal U23 v Crystal Palace U23 | W | 4-2 |
| England Premier League 2 | 2021/08/16 18:00 | West Ham U23 v Arsenal U23 | L | 6-1 |
| England Premier League 2 | 2021/05/07 18:00 | West Ham U23 v Arsenal U23 | D | 2-2 |