[4] STL Blues 5-2 Bonny/Tripet [6] 2022-01-17 20:00
Stadium: Canadian Tire Centre
Home Manager: Away Manager: Craig Berube
Head to Head
| NHL | 2019/10/10 23:30 | STL Blues v OTT Senators | W | 6-4 |
| NHL | 2019/03/14 23:30 | STL Blues v OTT Senators | L | 0-2 |
| NHL | 2019/01/20 00:00 | OTT Senators v STL Blues | W | 2-3 |
| NHL | 2018/01/24 01:00 | OTT Senators v STL Blues | W | 0-3 |
| NHL | 2018/01/19 00:30 | STL Blues v OTT Senators | W | 4-1 |
| NHL | 2017/02/08 00:30 | STL Blues v OTT Senators | W | 6-0 |
| NHL | 2017/01/18 01:00 | OTT Senators v STL Blues | L | 6-4 |
Home History
| NHL | 2022/01/16 00:00 | TOR Maple Leafs v STL Blues | L | 6-5 |
| NHL | 2022/01/14 01:00 | SEA Kraken v STL Blues | W | 1-2 |
| NHL | 2022/01/09 19:00 | DAL Stars v STL Blues | W | 1-2 |
| NHL | 2022/01/08 01:00 | WAS Capitals v STL Blues | W | 1-5 |
| NHL | 2022/01/06 00:30 | STL Blues v PIT Penguins | L | 3-5 |
| NHL | 2022/01/02 00:00 | STL Blues v MIN Wild | W | 6-4 |
| NHL | 2021/12/30 01:30 | EDM Oilers v STL Blues | W | 2-4 |
| NHL | 2021/12/19 20:00 | STL Blues v WPG Jets | L | 2-4 |
Away History
| NHL | 2022/01/16 03:00 | OTT Senators v EDM Oilers | W | 6-4 |
| NHL | 2022/01/14 02:00 | OTT Senators v CGY Flames | W | 4-1 |
| NHL | 2022/01/02 00:00 | OTT Senators v TOR Maple Leafs | L | 0-6 |
| NHL | 2021/12/19 00:00 | OTT Senators v PHI Flyers | L | 3-4 |
| NHL | 2021/12/17 00:00 | OTT Senators v TB Lightning | L | 1-2 |
| NHL | 2021/12/15 00:00 | OTT Senators v FLA Panthers | W | 8-2 |
| NHL | 2021/12/11 18:00 | TB Lightning v OTT Senators | W | 0-4 |
| NHL | 2021/12/08 00:00 | NY Islanders v OTT Senators | L | 5-3 |