[7] Real Santa Cruz 1-2 The Strongest [1] 2021-09-29 19:00
Stadium: Estadio Juan Carlos Duran Round: 4
Head to Head
| Bolivia Apertura | 2021/08/14 23:30 | The Strongest v Real Santa Cruz | W | 1-2 |
| Bolivia Apertura | 2020/12/02 23:00 | The Strongest v Real Santa Cruz | L | 4-2 |
| Bolivia Apertura | 2020/01/27 01:00 | Real Santa Cruz v The Strongest | W | 3-2 |
Home History
| Bolivia Apertura | 2021/09/27 19:00 | Real Santa Cruz v Guabira | W | 3-0 |
| Bolivia Apertura | 2021/09/21 23:00 | Real Potosi v Real Santa Cruz | L | 3-0 |
| Bolivia Apertura | 2021/09/18 19:00 | Real Santa Cruz v Royal Pari FC | W | 2-1 |
| Bolivia Apertura | 2021/09/14 19:00 | Always Ready v Real Santa Cruz | L | 4-0 |
| Bolivia Apertura | 2021/08/23 19:00 | Real Santa Cruz v Atletico Palmaflor Vinto | W | 1-0 |
| Bolivia Apertura | 2021/08/20 00:15 | Jorge Wilstermann v Real Santa Cruz | L | 5-1 |
| Bolivia Apertura | 2021/08/14 23:30 | The Strongest v Real Santa Cruz | W | 1-2 |
| Bolivia Apertura | 2021/08/07 19:00 | Real Santa Cruz v Oriente Petrolero | D | 0-0 |
Away History
| Bolivia Apertura | 2021/09/26 23:30 | The Strongest v Always Ready | D | 1-1 |
| Bolivia Apertura | 2021/09/22 22:15 | Atletico Palmaflor Vinto v The Strongest | D | 0-0 |
| Bolivia Apertura | 2021/09/19 21:15 | The Strongest v Jorge Wilstermann | W | 3-1 |
| Bolivia Apertura | 2021/09/12 23:30 | The Strongest v Independiente Petrolero | D | 1-1 |
| Bolivia Apertura | 2021/08/21 21:15 | Oriente Petrolero v The Strongest | L | 2-0 |
| Bolivia Apertura | 2021/08/18 19:00 | The Strongest v Nacional Potosi | W | 7-0 |
| Bolivia Apertura | 2021/08/14 23:30 | The Strongest v Real Santa Cruz | L | 1-2 |
| Bolivia Apertura | 2021/08/11 19:00 | Always Ready v The Strongest | L | 2-1 |