| Colombia Regional League | 2021/11/27 21:30 | CFD La Nororiental v Estudiantes de Medellin | D | 0-0 |
| Colombia Regional League | 2021/11/16 17:00 | Estudiantes de Medellin v Molino Viejo | L | 1-2 |
| Colombia Regional League | 2021/11/14 21:12 | Estudiantes de Medellin v CD Gallegol | W | 1-0 |
| Colombia Regional League | 2021/10/18 17:00 | Estudiantes de Medellin v Politecnico J.I.C. | W | 2-1 |
| Colombia Regional League | 2021/10/16 17:22 | Estudiantes de Medellin v CD Gallegol | W | 3-0 |
| Colombia Regional League | 2021/10/11 16:00 | Sellos Colombianos v Estudiantes de Medellin | L | 2-1 |
| Colombia Regional League | 2021/10/01 17:00 | FC Leones Reserves v Estudiantes de Medellin | L | 2-0 |
| Colombia Primera C | 2021/09/29 14:14 | Halcones de Sabaneta v Estudiantes de Medellin | W | 1-6 |
| Colombia Regional League | 2021/10/06 15:13 | Real Santuario v Inder Girardota | W | 5-0 |
| Colombia Primera C | 2021/09/02 17:10 | Antioquia FC v Real Santuario | W | 2-3 |
| Colombia Regional League | 2021/08/28 01:06 | Politecnico J.I.C. v Real Santuario | L | 2-1 |
| Colombia Primera C | 2021/08/26 17:00 | Politecnico J.I.C. v Real Santuario | L | 2-1 |
| Colombia Regional League | 2021/08/22 17:00 | Real Santuario v Deportivo Alexis Garcia | W | 2-1 |
| Colombia Primera C | 2021/08/10 17:00 | Real Santuario v Antioquia FC | L | 1-3 |
| Colombia Regional League | 2021/07/18 19:21 | CD Gallegol v Real Santuario | L | 3-2 |
| Colombia Regional League | 2021/07/04 17:16 | CD Los Del Sur v Real Santuario | W | 2-4 |