Head to Head
| MLB Spring Training | 2022/03/19 20:05 | CLE Guardians v CHI White Sox | L | 11-2 |
| MLB | 2021/09/26 17:10 | CHI White Sox v CLE Guardians | W | 5-2 |
| MLB | 2021/09/25 23:15 | CHI White Sox v CLE Guardians | L | 0-6 |
| MLB | 2021/09/24 23:10 | CHI White Sox v CLE Guardians | W | 1-0 |
| MLB | 2021/09/23 22:10 | CHI White Sox v CLE Guardians | L | 3-5 |
| MLB | 2021/09/23 17:10 | CHI White Sox v CLE Guardians | W | 7-2 |
| MLB | 2021/08/01 18:10 | CLE Guardians v CHI White Sox | W | 1-2 |
| MLB | 2021/07/31 23:10 | CLE Guardians v CHI White Sox | L | 12-11 |
Home History
| MLB | 2022/04/10 17:10 | CHI White Sox v DET Tigers | W | 10-1 |
| MLB | 2022/04/09 17:10 | CHI White Sox v DET Tigers | W | 5-2 |
| MLB | 2022/04/08 17:10 | CHI White Sox v DET Tigers | L | 4-5 |
| MLB Exhibition | 2022/04/05 19:10 | CHI White Sox v SD Padres | W | 9-6 |
| MLB Exhibition | 2022/04/04 20:05 | CHI White Sox v CHI Cubs | L | 9-15 |
| MLB Exhibition | 2022/04/03 20:05 | COL Rockies v CHI White Sox | L | 13-4 |
| MLB Exhibition | 2022/04/03 01:10 | CHI White Sox v ARI Diamondbacks | L | 4-8 |
| MLB Exhibition | 2022/04/01 20:05 | OAK Athletics v CHI White Sox | L | 12-4 |
Away History
| MLB | 2022/04/10 18:10 | CLE Guardians v KC Royals | W | 17-3 |
| MLB | 2022/04/09 20:10 | CLE Guardians v KC Royals | L | 0-1 |
| MLB | 2022/04/07 20:10 | CLE Guardians v KC Royals | L | 1-3 |
| MLB Spring Training | 2022/04/05 20:10 | COL Rockies v CLE Guardians | L | 10-3 |
| MLB Spring Training | 2022/04/05 19:40 | ARI Diamondbacks v CLE Guardians | L | 3-1 |
| MLB Spring Training | 2022/04/05 01:40 | ARI Diamondbacks v CLE Guardians | L | 3-1 |
| MLB Exhibition | 2022/04/04 01:05 | CHI Cubs v CLE Guardians | L | 7-3 |
| MLB Exhibition | 2022/04/03 01:05 | CLE Guardians v TEX Rangers | L | 1-3 |