Stadium: Chalmers Field Round: 1
| NCAAF | 2021/11/13 19:00 | Dubuque Spartans v Loras Duhawks | W | 17-14 |
| NCAAF | 2021/11/06 18:00 | Central Dutch v Dubuque Spartans | L | 56-7 |
| NCAAF | 2021/10/30 18:00 | Dubuque Spartans v Coe Kohawks | L | 27-34 |
| NCAAF | 2021/10/23 18:00 | Wartburg Knights v Dubuque Spartans | L | 27-7 |
| NCAAF | 2021/10/16 19:00 | Dubuque Spartans v Simpson Storm | W | 41-28 |
| NCAAF | 2021/10/09 18:00 | Nebraska Wesleyan Prairie Wolves v Dubuque Spartans | W | 14-31 |
| NCAAF | 2021/10/02 18:00 | Dubuque Spartans v Buena Vista Beavers | W | 31-16 |
| NCAAF | 2021/09/18 18:00 | Luther Norse v Dubuque Spartans | W | 2-28 |
| NCAAF | 2021/11/27 18:00 | North Central Illinois v Uw-La Crosse Eagles | L | 34-20 |
| NCAAF | 2021/11/20 17:00 | Albion Britons v Uw-La Crosse Eagles | W | 23-58 |
| NCAAF | 2021/11/13 17:30 | Uw-La Crosse Eagles v Uw-Eau Claire Blugolds | W | 44-20 |
| NCAAF | 2021/11/06 18:00 | UW-Whitewater v Uw-La Crosse Eagles | L | 13-7 |
| NCAAF | 2021/10/30 18:00 | Uw-Stevens Point Pointers v Uw-La Crosse Eagles | W | 3-56 |
| NCAAF | 2021/10/23 18:00 | Uw-La Crosse Eagles v Uw-Stout Blue Devils | W | 44-38 |
| NCAAF | 2021/10/16 18:00 | Uw-Platteville Pioneers v Uw-La Crosse Eagles | W | 23-24 |
| NCAAF | 2021/10/09 19:00 | Uw-La Crosse Eagles v Wisconsin Oshkosh | W | 30-21 |