Stadium: Charles A Henry Athletic Field Round: 1
| NCAAF | 2021/10/02 17:00 | Depauw Tigers v Hiram Terriers | L | 57-7 |
| NCAAF | 2019/10/12 17:00 | Hiram Terriers v Depauw Tigers | L | 7-21 |
| NCAAF | 2018/09/15 17:00 | Depauw Tigers v Hiram Terriers | L | 45-7 |
| NCAAF | 2021/11/13 18:00 | Kenyon Lords v Hiram Terriers | L | 21-16 |
| NCAAF | 2021/11/06 17:00 | Hiram Terriers v Denison Big Red | L | 6-59 |
| NCAAF | 2021/10/30 16:00 | Wooster Scots v Hiram Terriers | L | 51-14 |
| NCAAF | 2021/10/23 17:00 | Hiram Terriers v Oberlin Yeomen | L | 28-31 |
| NCAAF | 2021/10/16 17:00 | Hiram Terriers v Allegheny Gators | L | 13-38 |
| NCAAF | 2021/10/09 17:00 | Ohio Wesleyan Battling Bishops v Hiram Terriers | L | 34-17 |
| NCAAF | 2021/10/02 17:00 | Depauw Tigers v Hiram Terriers | L | 57-7 |
| NCAAF | 2021/09/18 20:30 | Wittenberg Tigers v Hiram Terriers | L | 51-21 |
| NCAAF | 2021/11/27 18:00 | UW-Whitewater v Depauw Tigers | L | 45-0 |
| NCAAF | 2021/11/20 17:00 | Depauw Tigers v Rose Hulman Engineers | W | 26-21 |
| NCAAF | 2021/11/13 18:07 | Wabash Little Giants v Depauw Tigers | L | 42-35 |
| NCAAF | 2021/11/06 17:00 | Depauw Tigers v Oberlin Yeomen | W | 66-13 |
| NCAAF | 2021/10/30 17:00 | Depauw Tigers v Denison Big Red | W | 27-10 |
| NCAAF | 2021/10/23 17:00 | Allegheny Gators v Depauw Tigers | W | 14-38 |
| NCAAF | 2021/10/16 17:00 | Depauw Tigers v Ohio Wesleyan Battling Bishops | W | 24-7 |
| NCAAF | 2021/10/09 18:00 | Wittenberg Tigers v Depauw Tigers | W | 14-17 |