Stadium: Reynolds Field Round: 1
| NCAAF | 2021/11/18 00:00 | Northwestern Eagles v Crown Storm | W | 59-20 |
| NCAAF | 2021/11/13 19:00 | Martin Luther Knights v Northwestern Eagles | L | 27-21 |
| NCAAF | 2021/10/30 23:00 | Minnesota Morris Cougars v Northwestern Eagles | L | 28-21 |
| NCAAF | 2021/10/23 17:00 | Northwestern Eagles v Westminster Blue Jays | W | 45-28 |
| NCAAF | 2021/10/09 17:00 | Greenville Panthers v Northwestern Eagles | L | 35-23 |
| NCAAF | 2021/10/02 17:00 | Northwestern Eagles v Finlandia Lions | W | 16-13 |
| NCAAF | 2021/09/25 17:00 | Hope Flying Dutchmen v Northwestern Eagles | L | 52-10 |
| NCAAF | 2021/09/18 23:00 | Northwestern Eagles v Uw-River Falls Falcons | L | 13-71 |
| NCAAF | 2021/11/13 18:00 | Trine Thunder v Hope Flying Dutchmen | W | 13-17 |
| NCAAF | 2021/11/06 17:00 | Hope Flying Dutchmen v Albion Britons | L | 38-41 |
| NCAAF | 2021/10/30 17:00 | Alma College Scots v Hope Flying Dutchmen | W | 3-27 |
| NCAAF | 2021/10/23 18:00 | Hope Flying Dutchmen v Adrian Bulldogs | W | 19-7 |
| NCAAF | 2021/10/16 17:00 | Olivet Comets v Hope Flying Dutchmen | W | 16-31 |
| NCAAF | 2021/10/02 17:00 | Hope Flying Dutchmen v Kalamazoo Hornets | W | 67-0 |
| NCAAF | 2021/09/25 17:00 | Hope Flying Dutchmen v Northwestern Eagles | W | 52-10 |
| NCAAF | 2021/09/18 18:00 | Hope Flying Dutchmen v Rose Hulman Engineers | W | 27-20 |