Stadium: Fred Zollner Athletic Stadium Round: 1
| NCAAF | 2021/11/13 18:00 | Trine Thunder v Hope Flying Dutchmen | L | 13-17 |
| NCAAF | 2021/11/06 17:00 | Alma College Scots v Trine Thunder | W | 23-37 |
| NCAAF | 2021/10/30 17:00 | Albion Britons v Trine Thunder | L | 31-24 |
| NCAAF | 2021/10/23 17:00 | Trine Thunder v Kalamazoo Hornets | W | 47-13 |
| NCAAF | 2021/10/09 18:00 | Olivet Comets v Trine Thunder | W | 14-35 |
| NCAAF | 2021/10/02 17:00 | Trine Thunder v Adrian Bulldogs | W | 36-20 |
| NCAAF | 2021/09/25 23:00 | Centre Colonels v Trine Thunder | L | 14-7 |
| NCAAF | 2021/09/18 17:00 | Trine Thunder v Mount St. Joseph Lions | W | 31-30 |
| NCAAF | 2021/11/13 19:00 | Berry Vikings v Centre Colonels | W | 27-49 |
| NCAAF | 2021/11/06 18:30 | Sewanee Tigers v Centre Colonels | W | 20-30 |
| NCAAF | 2021/10/30 17:00 | Centre Colonels v Rhodes Lynx | W | 49-6 |
| NCAAF | 2021/10/23 17:00 | Millsaps Majors v Centre Colonels | W | 34-66 |
| NCAAF | 2021/10/16 17:00 | Centre Colonels v Birmingham Southern Panthers | L | 21-28 |
| NCAAF | 2021/10/09 18:30 | Trinity Tigers v Centre Colonels | L | 27-7 |
| NCAAF | 2021/10/02 17:00 | Centre Colonels v Hendrix Warriors | W | 42-21 |
| NCAAF | 2021/09/25 23:00 | Centre Colonels v Trine Thunder | W | 14-7 |