Stadium: Shuford Stadium Round: 1
| NCAAF | 2021/10/30 17:00 | Catawba College v Tusculum Pioneers | W | 31-28 |
| NCAAF | 2019/11/02 18:30 | Tusculum Pioneers v Catawba College | L | 32-14 |
| NCAAF | 2018/10/20 17:30 | Catawba College v Tusculum Pioneers | W | 55-37 |
| NCAAF | 2021/11/13 18:00 | Lenoir Rhyne Bears v Catawba College | L | 56-3 |
| NCAAF | 2021/11/06 17:00 | Catawba College v Virginia Wise Highland Cavaliers | L | 7-30 |
| NCAAF | 2021/10/30 17:00 | Catawba College v Tusculum Pioneers | W | 31-28 |
| NCAAF | 2021/10/23 17:00 | Mars Hill Lions v Catawba College | L | 31-14 |
| NCAAF | 2021/10/16 21:00 | Newberry Wolves v Catawba College | L | 14-7 |
| NCAAF | 2021/10/09 17:00 | Catawba College v Carson–Newman Eagles | W | 33-27 |
| NCAAF | 2021/09/18 17:00 | Catawba College v Barton Bulldogs | W | 17-10 |
| NCAAF | 2021/09/11 23:00 | Catawba College v Winston-Salem State | W | 28-6 |
| NCAAF | 2021/11/13 18:30 | Tusculum Pioneers v Carson–Newman Eagles | W | 48-13 |
| NCAAF | 2021/11/06 17:00 | Mars Hill Lions v Tusculum Pioneers | L | 20-7 |
| NCAAF | 2021/10/30 17:00 | Catawba College v Tusculum Pioneers | L | 31-28 |
| NCAAF | 2021/10/23 18:00 | Tusculum Pioneers v Barton Bulldogs | W | 41-17 |
| NCAAF | 2021/10/16 17:30 | Tusculum Pioneers v Virginia Wise Highland Cavaliers | W | 37-21 |
| NCAAF | 2021/10/09 18:00 | Lenoir Rhyne Bears v Tusculum Pioneers | L | 38-31 |
| NCAAF | 2021/10/02 22:00 | Wingate Bulldogs v Tusculum Pioneers | L | 43-35 |
| NCAAF | 2021/09/25 17:30 | Tusculum Pioneers v Newberry Wolves | L | 19-24 |