Stadium: Bob Shelton Stadium Round: 1
| NCAAF | 2021/09/25 23:00 | Mary Hardin Baylor v Hardin Simmons Cowboys | L | 34-28 |
| NCAAF | 2019/10/26 18:00 | Mary Hardin Baylor v Hardin Simmons Cowboys | L | 15-14 |
| NCAAF | 2018/11/17 18:00 | Mary Hardin Baylor v Hardin Simmons Cowboys | L | 27-6 |
| NCAAF | 2018/10/06 23:00 | Mary Hardin Baylor v Hardin Simmons Cowboys | L | 26-0 |
| NCAAF | 2021/11/13 19:00 | Hardin Simmons Cowboys v Texas Lutheran Bulldogs | W | 65-0 |
| NCAAF | 2021/11/06 18:00 | Austin Kangaroos v Hardin Simmons Cowboys | W | 14-56 |
| NCAAF | 2021/10/30 18:00 | Howard Payne Yellow Jackets v Hardin Simmons Cowboys | W | 14-38 |
| NCAAF | 2021/10/23 18:00 | Hardin Simmons Cowboys v Southwestern Pirates | W | 69-7 |
| NCAAF | 2021/10/16 18:00 | East Texas Baptist Tigers v Hardin Simmons Cowboys | W | 0-34 |
| NCAAF | 2021/10/02 18:00 | Hardin Simmons Cowboys v Mcmurry Warhawks | W | 24-21 |
| NCAAF | 2021/09/25 23:00 | Mary Hardin Baylor v Hardin Simmons Cowboys | L | 34-28 |
| NCAAF | 2021/09/18 18:00 | Hardin Simmons Cowboys v Belhaven Blazers | W | 21-16 |
| NCAAF | 2021/12/18 00:00 | North Central Illinois v Mary Hardin Baylor | W | 24-57 |
| NCAAF | 2021/12/18 00:00 | Mary Hardin Baylor v North Central Illinois | W | 57-24 |
| NCAAF | 2021/12/11 20:30 | Mary Hardin Baylor v UW-Whitewater | W | 24-7 |
| NCAAF | 2021/12/04 18:00 | Linfield Wildcats v Mary Hardin Baylor | W | 24-49 |
| NCAAF | 2021/11/27 18:00 | Mary Hardin Baylor v Birmingham Southern Panthers | W | 42-7 |
| NCAAF | 2021/11/20 18:00 | Mary Hardin Baylor v Trinity Tigers | W | 13-3 |
| NCAAF | 2021/11/13 19:00 | Mcmurry Warhawks v Mary Hardin Baylor | W | 3-77 |
| NCAAF | 2021/11/06 18:00 | Mary Hardin Baylor v Howard Payne Yellow Jackets | W | 59-14 |