Stadium: Growney Stadium Round: 1
| NCAAF | 2021/11/13 18:00 | Utica Pioneers v St John Fisher Cardinals | L | 35-14 |
| NCAAF | 2021/11/06 17:00 | St John Fisher Cardinals v Cortland Red Dragons | L | 3-55 |
| NCAAF | 2021/10/30 18:30 | Hartwick Hawks v St John Fisher Cardinals | W | 7-28 |
| NCAAF | 2021/10/16 17:00 | St John Fisher Cardinals v Alfred Saxons | L | 35-38 |
| NCAAF | 2021/10/09 17:00 | Morrisville State Mustangs v St John Fisher Cardinals | W | 23-28 |
| NCAAF | 2021/10/02 22:00 | St John Fisher Cardinals v Brockport Golden Eagles | L | 7-34 |
| NCAAF | 2021/09/25 16:00 | Rpi Engineers v St John Fisher Cardinals | L | 41-7 |
| NCAAF | 2021/09/18 18:00 | St John Fisher Cardinals v Hobart Statesmen | L | 21-42 |
| NCAAF | 2021/12/04 18:00 | North Central Illinois v Rpi Engineers | L | 55-6 |
| NCAAF | 2021/11/27 17:00 | Cortland Red Dragons v Rpi Engineers | W | 14-21 |
| NCAAF | 2021/11/20 17:00 | Endicott Gulls v Rpi Engineers | W | 14-20 |
| NCAAF | 2021/11/13 17:00 | Union Dutchmen v Rpi Engineers | W | 17-19 |
| NCAAF | 2021/11/13 16:00 | Union College Bulldogs v Rpi Engineers | W | 17-19 |
| NCAAF | 2021/11/06 17:00 | St Lawrence Saints v Rpi Engineers | W | 20-22 |
| NCAAF | 2021/10/30 16:00 | Rpi Engineers v Ithaca Bombers | W | 14-11 |
| NCAAF | 2021/10/16 17:00 | Hobart Statesmen v Rpi Engineers | L | 10-9 |