Stadium: Cook Stadium Round: 1
| NCAAF | 2021/10/23 17:30 | Manchester Spartans v Rose Hulman Engineers | W | 14-57 |
| NCAAF | 2019/09/28 17:30 | Manchester Spartans v Rose Hulman Engineers | W | 35-52 |
| NCAAF | 2018/09/22 23:00 | Rose Hulman Engineers v Manchester Spartans | W | 19-12 |
| NCAAF | 2021/11/20 17:00 | Depauw Tigers v Rose Hulman Engineers | L | 26-21 |
| NCAAF | 2021/11/13 18:30 | Rose Hulman Engineers v Mount St. Joseph Lions | W | 58-21 |
| NCAAF | 2021/11/06 17:30 | Franklin College Grizzlies v Rose Hulman Engineers | W | 14-38 |
| NCAAF | 2021/10/30 17:30 | Rose Hulman Engineers v Bluffton Beavers | W | 48-12 |
| NCAAF | 2021/10/23 17:30 | Manchester Spartans v Rose Hulman Engineers | W | 14-57 |
| NCAAF | 2021/10/16 17:30 | Rose Hulman Engineers v Anderson Ravens | W | 62-7 |
| NCAAF | 2021/10/09 18:00 | Rose Hulman Engineers v Hanover | W | 31-21 |
| NCAAF | 2021/10/02 17:30 | Defiance Yellow Jackets v Rose Hulman Engineers | W | 14-63 |
| NCAAF | 2021/11/13 18:30 | Manchester Spartans v Anderson Ravens | W | 3-0 |
| NCAAF | 2021/11/06 17:30 | Bluffton Beavers v Manchester Spartans | L | 31-7 |
| NCAAF | 2021/10/30 17:30 | Hanover v Manchester Spartans | L | 33-0 |
| NCAAF | 2021/10/23 17:30 | Manchester Spartans v Rose Hulman Engineers | L | 14-57 |
| NCAAF | 2021/10/16 17:30 | Mount St. Joseph Lions v Manchester Spartans | L | 28-0 |
| NCAAF | 2021/10/09 17:30 | Manchester Spartans v Defiance Yellow Jackets | W | 22-0 |
| NCAAF | 2021/10/02 17:30 | Franklin College Grizzlies v Manchester Spartans | W | 24-27 |
| NCAAF | 2021/09/18 17:00 | Olivet Comets v Manchester Spartans | L | 59-7 |