Stadium: Chad Richison Stadium Round: 1
| NCAAF | 2021/10/17 00:00 | Fort Hays State University Tigers v Central Oklahoma | W | 14-24 |
| NCAAF | 2019/10/05 18:00 | Central Oklahoma v Fort Hays State University Tigers | L | 7-35 |
| NCAAF | 2018/09/30 00:00 | Fort Hays State University Tigers v Central Oklahoma | L | 15-0 |
| NCAAF | 2021/11/13 19:00 | Central Missouri Mules v Central Oklahoma | L | 30-29 |
| NCAAF | 2021/11/06 19:00 | Nebraska Kearney v Central Oklahoma | L | 37-22 |
| NCAAF | 2021/10/30 18:00 | Pittsburgh State Gorillas v Central Oklahoma | L | 26-20 |
| NCAAF | 2021/10/23 19:00 | Central Oklahoma v Washburn Ichabods Football | L | 17-29 |
| NCAAF | 2021/10/17 00:00 | Fort Hays State University Tigers v Central Oklahoma | W | 14-24 |
| NCAAF | 2021/10/08 00:00 | Northeastern State Riverhawks v Central Oklahoma | W | 9-49 |
| NCAAF | 2021/10/02 19:00 | Central Oklahoma v Blue Tigers | W | 69-28 |
| NCAAF | 2021/09/25 18:30 | NW Missouri State v Central Oklahoma | L | 38-0 |
| NCAAF | 2021/11/13 19:00 | Fort Hays State University Tigers v Pittsburgh State Gorillas | L | 24-34 |
| NCAAF | 2021/10/30 18:00 | Fort Hays State University Tigers v Emporia State | L | 12-15 |
| NCAAF | 2021/10/23 18:30 | Central Missouri Mules v Fort Hays State University Tigers | W | 17-21 |
| NCAAF | 2021/10/17 00:00 | Fort Hays State University Tigers v Central Oklahoma | L | 14-24 |
| NCAAF | 2021/10/09 18:00 | Washburn Ichabods Football v Fort Hays State University Tigers | L | 23-20 |
| NCAAF | 2021/10/03 00:00 | Fort Hays State University Tigers v Nebraska Kearney | W | 42-35 |
| NCAAF | 2021/09/25 19:00 | Missouri Southern Lions v Fort Hays State University Tigers | W | 21-42 |
| NCAAF | 2021/09/19 00:00 | Fort Hays State University Tigers v Blue Tigers | W | 72-0 |