Stadium: McConnell Family Stadium Round: 1
| NCAAF | 2021/11/13 18:05 | East Stroudsburg Warriors v Gannon University Golden Knights | W | 10-13 |
| NCAAF | 2021/11/06 16:00 | Mercyhurst v Gannon University Golden Knights | L | 24-13 |
| NCAAF | 2021/10/30 16:00 | Gannon University Golden Knights v Slippery Rock | L | 21-63 |
| NCAAF | 2021/10/23 16:00 | Gannon University Golden Knights v Edinboro | W | 21-18 |
| NCAAF | 2021/10/16 20:00 | Seton Hill Griffins v Gannon University Golden Knights | W | 10-14 |
| NCAAF | 2021/10/09 16:00 | Gannon University Golden Knights v California Vulcans | L | 17-38 |
| NCAAF | 2021/10/02 18:00 | Iup Crimson Hawks v Gannon University Golden Knights | L | 28-23 |
| NCAAF | 2021/09/25 17:00 | Gannon University Golden Knights v Clarion Golden Eagles | W | 56-21 |
| NCAAF | 2021/11/13 18:00 | Shippensburg Raiders v Mercyhurst | W | 17-13 |
| NCAAF | 2021/11/06 17:00 | Shippensburg Raiders v Lock Haven | W | 52-14 |
| NCAAF | 2021/10/30 17:05 | East Stroudsburg Warriors v Shippensburg Raiders | W | 23-24 |
| NCAAF | 2021/10/23 17:00 | Shippensburg Raiders v Millersville University of Pennsylvania Marauders | W | 38-7 |
| NCAAF | 2021/10/16 21:00 | Kutztown Golden Bears v Shippensburg Raiders | L | 20-3 |
| NCAAF | 2021/10/09 17:00 | Shippensburg Raiders v West Chester Golden Rams | W | 34-18 |
| NCAAF | 2021/10/02 16:00 | Shepherd Rams v Shippensburg Raiders | L | 59-27 |
| NCAAF | 2021/09/25 17:00 | Shippensburg Raiders v Bloomsburg Huskies | W | 51-7 |