Stadium: Stisser Field at the Knosher Bowl Round: 1
| NCAAF | 2021/10/23 18:00 | Illinois College Blueboys v Knox Prairie Fire | L | 27-20 |
| NCAAF | 2019/10/26 18:00 | Illinois College Blueboys v Knox Prairie Fire | L | 47-17 |
| NCAAF | 2018/10/20 18:00 | Knox Prairie Fire v Illinois College Blueboys | W | 20-6 |
| NCAAF | 2021/11/13 18:00 | Monmouth Scots v Knox Prairie Fire | L | 38-7 |
| NCAAF | 2021/11/06 18:00 | Knox Prairie Fire v Cornell Rams | L | 34-35 |
| NCAAF | 2021/10/30 18:00 | Knox Prairie Fire v Lawrence Vikings | W | 56-28 |
| NCAAF | 2021/10/23 18:00 | Illinois College Blueboys v Knox Prairie Fire | L | 27-20 |
| NCAAF | 2021/10/16 18:00 | Grinnell Pioneers v Knox Prairie Fire | W | 28-49 |
| NCAAF | 2021/10/09 18:00 | Knox Prairie Fire v Beloit Buccaneers | W | 42-0 |
| NCAAF | 2021/10/02 19:00 | Chicago Maroons v Knox Prairie Fire | L | 45-10 |
| NCAAF | 2021/09/18 19:00 | Knox Prairie Fire v Lake Forest Foresters | L | 10-41 |
| NCAAF | 2021/11/13 18:00 | Beloit Buccaneers v Illinois College Blueboys | W | 3-21 |
| NCAAF | 2021/11/06 18:00 | Illinois College Blueboys v Grinnell Pioneers | W | 55-24 |
| NCAAF | 2021/10/30 18:00 | Cornell Rams v Illinois College Blueboys | W | 7-39 |
| NCAAF | 2021/10/23 18:00 | Illinois College Blueboys v Knox Prairie Fire | W | 27-20 |
| NCAAF | 2021/10/16 18:00 | Lawrence Vikings v Illinois College Blueboys | W | 37-38 |
| NCAAF | 2021/10/09 18:00 | Illinois College Blueboys v Lake Forest Foresters | L | 13-48 |
| NCAAF | 2021/10/02 18:00 | Ripon Red Hawks v Illinois College Blueboys | L | 24-13 |
| NCAAF | 2021/09/18 18:00 | Illinois College Blueboys v Monmouth Scots | L | 27-37 |