Stadium: Edwin Fauver Stadium Round: 1
| NCAAF | 2021/11/13 17:00 | Rochester Yellowjackets v Hobart Statesmen | L | 0-31 |
| NCAAF | 2021/11/06 17:00 | Hartwick Hawks v Rochester Yellowjackets | W | 28-42 |
| NCAAF | 2021/10/30 17:00 | St Lawrence Saints v Rochester Yellowjackets | L | 34-10 |
| NCAAF | 2021/10/23 16:00 | Rochester Yellowjackets v Union Dutchmen | L | 9-35 |
| NCAAF | 2021/10/16 20:00 | Buffalo State Bengals v Rochester Yellowjackets | W | 7-14 |
| NCAAF | 2021/10/09 16:00 | Rochester Yellowjackets v Ithaca Bombers | L | 14-37 |
| NCAAF | 2021/10/02 16:00 | Rpi Engineers v Rochester Yellowjackets | L | 38-22 |
| NCAAF | 2021/09/18 16:00 | Brockport Golden Eagles v Rochester Yellowjackets | L | 16-7 |
| NCAAF | 2021/11/13 18:00 | Hartwick Hawks v Morrisville State Mustangs | W | 14-7 |
| NCAAF | 2021/11/06 17:00 | Hartwick Hawks v Rochester Yellowjackets | L | 28-42 |
| NCAAF | 2021/10/30 18:30 | Hartwick Hawks v St John Fisher Cardinals | L | 7-28 |
| NCAAF | 2021/10/23 17:00 | Brockport Golden Eagles v Hartwick Hawks | L | 41-14 |
| NCAAF | 2021/10/16 17:00 | Hartwick Hawks v Cortland Red Dragons | L | 3-48 |
| NCAAF | 2021/10/09 21:00 | Alfred Saxons v Hartwick Hawks | L | 24-21 |
| NCAAF | 2021/10/02 18:30 | Hartwick Hawks v Utica Pioneers | L | 10-16 |
| NCAAF | 2021/09/18 20:00 | Curry Colonels v Hartwick Hawks | L | 14-7 |