| Colombia Regional League | 2022/05/30 17:23 | Sol de Oriente v Real Santuario | L | 2-1 |
| Colombia Regional League | 2022/05/24 17:12 | Real Santuario v Politecnico J.I.C. | W | 3-0 |
| Colombia Regional League | 2022/05/10 13:15 | Real Santuario v Envigado FC Reserves | L | 1-3 |
| Colombia Regional League | 2022/04/23 17:18 | Real Santuario v FC Leones Reserves | D | 2-2 |
| Colombia Regional League | 2022/04/11 16:00 | Estudiantes de Medellin v Real Santuario | D | 1-1 |
| Colombia Regional League | 2022/03/27 13:12 | Real Santuario v Deportivo Alexis Garcia | L | 0-2 |
| Colombia Regional League | 2022/03/01 17:13 | E.D.P IND. Medellin v Real Santuario | L | 2-0 |
| Colombia Regional League | 2021/10/06 15:13 | Real Santuario v Inder Girardota | W | 5-0 |
| Colombia Regional League | 2022/05/24 15:00 | FC Leones Reserves v Atletico Nacional Medellin Reserves | L | 2-1 |
| Colombia Regional League | 2022/05/10 17:13 | Universidad de Antioquia v Atletico Nacional Medellin Reserves | W | 0-1 |
| Colombia Regional League | 2022/04/23 16:00 | Independiente Sabaneta v Atletico Nacional Medellin Reserves | D | 0-0 |
| Colombia Regional League | 2022/03/22 17:14 | Talento y Vida v Atletico Nacional Medellin Reserves | W | 0-5 |
| Colombia Regional League | 2021/11/27 19:24 | Atletico Nacional Medellin Reserves v Deportivo Alexis Garcia | W | 2-0 |
| Colombia Regional League | 2021/09/04 21:14 | Aguilas Doradas Reserves v Atletico Nacional Medellin Reserves | L | 2-1 |
| Colombia Regional League | 2021/07/31 21:06 | Inder Girardota v Atletico Nacional Medellin Reserves | W | 1-2 |
| Colombia Regional League | 2021/07/04 13:00 | Atletico Nacional Medellin Reserves v Deportivo Alexis Garcia | W | 1-0 |