Stadium: George M. Holmes Convocation Center
Home Manager: Jeff Jones Away Manager: Dustin Kerns
| NCAAB | 2022/03/10 02:00 | Old Dominion v UTEP | L | 64-74 |
| NCAAB | 2022/03/05 19:00 | Middle Tenn St v Old Dominion | W | 64-68 |
| NCAAB | 2022/03/03 00:00 | Old Dominion v Louisiana Tech | L | 54-67 |
| NCAAB | 2022/02/27 00:00 | Florida Intl v Old Dominion | W | 63-83 |
| NCAAB | 2022/02/25 00:00 | Florida Atlantic v Old Dominion | W | 51-70 |
| NCAAB | 2022/02/20 00:00 | Old Dominion v Western Kentucky | L | 64-73 |
| NCAAB | 2022/02/18 00:00 | Old Dominion v Marshall | L | 63-67 |
| NCAAB | 2022/02/13 19:00 | UAB v Old Dominion | W | 72-81 |
| NCAAB | 2022/03/15 22:30 | USC Upstate v Appalachian State | L | 80-74 |
| NCAAB | 2022/03/07 01:30 | Georgia State v Appalachian State | L | 71-66 |
| NCAAB | 2022/03/06 01:30 | Georgia Southern v Appalachian State | W | 60-73 |
| NCAAB | 2022/02/26 01:00 | Appalachian State v Arkansas State | L | 60-62 |
| NCAAB | 2022/02/24 00:30 | Appalachian State v Arkansas LR | W | 78-66 |
| NCAAB | 2022/02/19 21:30 | South Alabama v Appalachian State | W | 51-69 |
| NCAAB | 2022/02/17 23:30 | Troy v Appalachian State | L | 67-61 |
| NCAAB | 2022/02/12 21:00 | Georgia State v Appalachian State | L | 58-49 |