Clemson 39-10 North Carolina 2022-08-17 17:00
Stadium: Bank of America Stadium Round: 1
Home Manager: Dabo Swinney Away Manager: Mack Brown
Head to Head
| NCAAF | 2019/09/28 19:30 | Clemson v North Carolina | W | 21-20 |
| NCAAF | 2015/12/06 01:00 | Clemson v North Carolina | W | 45-37 |
| NCAAF | 2014/09/27 23:00 | Clemson v North Carolina | W | 50-35 |
| NCAAF | 2011/10/22 12:00 | Clemson v North Carolina | W | 59-38 |
| NCAAF | 2010/10/09 12:00 | North Carolina v Clemson | L | 21-16 |
| NCAAF | 2006/09/23 12:00 | Clemson v North Carolina | W | 52-7 |
| NCAAF | 2003/10/25 12:00 | Clemson v North Carolina | W | 36-28 |
| NCAAF | 2002/11/09 12:00 | North Carolina v Clemson | W | 12-42 |
Home History
| NCAAF Bowl Games | 2021/12/29 22:45 | Iowa State v Clemson | W | 13-20 |
| NCAAF | 2021/11/28 00:30 | Clemson v South Carolina | W | 30-0 |
| NCAAF | 2021/11/20 17:00 | Wake Forest v Clemson | W | 27-48 |
| NCAAF | 2021/11/13 17:00 | Connecticut v Clemson | W | 7-44 |
| NCAAF | 2021/11/06 23:30 | Clemson v Louisville | W | 30-24 |
| NCAAF | 2021/10/30 19:30 | Florida State v Clemson | W | 20-30 |
| NCAAF | 2021/10/23 19:30 | Clemson v Pittsburgh | L | 17-27 |
| NCAAF | 2021/10/15 23:00 | Clemson v Syracuse | W | 17-14 |
Away History
| NCAAF Bowl Games | 2021/12/30 16:30 | South Carolina v North Carolina | L | 38-21 |
| NCAAF | 2021/11/27 00:00 | North Carolina v NC State | L | 30-34 |
| NCAAF | 2021/11/20 17:00 | Wofford v North Carolina | W | 14-34 |
| NCAAF | 2021/11/12 00:30 | North Carolina v Pittsburgh | L | 23-30 |
| NCAAF | 2021/11/06 16:00 | Wake Forest v North Carolina | W | 55-58 |
| NCAAF | 2021/10/30 23:30 | North Carolina v Notre Dame | L | 34-44 |
| NCAAF | 2021/10/16 19:30 | Miami Florida v North Carolina | W | 42-45 |
| NCAAF | 2021/10/09 19:30 | Florida State v North Carolina | L | 35-25 |