[2] El Tanque Sisley 2-1 Independiente Medellin [3] 2022-12-17 14:00
Stadium: Estadio Gran Parque Central Round: 2
Referee: Dario Herrera Home Manager: Alvaro Gutierrez Pelscher Away Manager: David Gonzalez
Home History
| Uruguay Clausura | 2022/10/30 19:00 | Liverpool Montevideo v Nacional De Football | D | 1-1 |
| Uruguay Clausura | 2022/10/23 22:30 | Nacional De Football v Danubio | W | 2-0 |
| Uruguay Clausura | 2022/10/17 23:30 | Cerrito v Nacional De Football | W | 1-2 |
| Uruguay Clausura | 2022/10/13 22:00 | Albion FC v Nacional De Football | W | 0-1 |
| Uruguay Clausura | 2022/10/08 22:30 | Nacional De Football v Defensor Sporting | D | 1-1 |
| Uruguay Clausura | 2022/10/01 21:00 | Atletico Fenix Montevideo v Nacional De Football | D | 1-1 |
| Uruguay Clausura | 2022/09/25 21:00 | Nacional De Football v Cerro Largo | D | 1-1 |
| Uruguay Cup | 2022/09/21 23:00 | Rampla Juniors v Nacional De Football | L | 3-0 |
Away History
| Colombia Primera A | 2022/12/08 00:00 | Deportivo Pereira v Independiente Medellin | D | 0-0 |
| Colombia Primera A | 2022/12/04 23:00 | Independiente Medellin v Deportivo Pereira | D | 1-1 |
| Colombia Primera A | 2022/11/30 23:30 | Deportivo Pasto v Independiente Medellin | D | 0-0 |
| Colombia Primera A | 2022/11/27 01:05 | Independiente Medellin v America de Cali | W | 2-1 |
| Colombia Primera A | 2022/11/23 01:35 | Independiente Medellin v Aguilas Doradas | W | 2-1 |
| Colombia Primera A | 2022/11/13 00:00 | Aguilas Doradas v Independiente Medellin | L | 1-0 |
| Colombia Primera A | 2022/11/09 01:20 | America de Cali v Independiente Medellin | W | 0-2 |
| Colombia Primera A | 2022/11/06 00:30 | Independiente Medellin v Deportivo Pasto | D | 0-0 |