Stadium: Panther Stadium Round: 1
| NCAAF | 2022/10/08 16:00 | Lake Erie v Ohio Dominican Panthers | W | 7-38 |
| NCAAF | 2021/11/06 16:00 | Ohio Dominican Panthers v Lake Erie | W | 31-0 |
| NCAAF | 2019/11/09 18:00 | Ohio Dominican Panthers v Lake Erie | W | 49-10 |
| NCAAF | 2018/11/10 17:00 | Lake Erie v Ohio Dominican Panthers | W | 6-62 |
| NCAAF | 2022/11/12 18:00 | Ohio Dominican Panthers v Hillsdale Chargers | W | 20-10 |
| NCAAF | 2022/11/05 17:00 | Northwood Timberwolves v Ohio Dominican Panthers | W | 24-35 |
| NCAAF | 2022/10/22 17:00 | Ohio Dominican Panthers v Kentucky Wesleyan | W | 49-7 |
| NCAAF | 2022/10/15 23:00 | Ashland Eagles v Ohio Dominican Panthers | L | 14-7 |
| NCAAF | 2022/10/08 16:00 | Lake Erie v Ohio Dominican Panthers | W | 7-38 |
| NCAAF | 2022/10/01 17:00 | Ohio Dominican Panthers v Walsh U. Cavaliers | W | 21-0 |
| NCAAF | 2022/09/24 17:00 | Ohio Dominican Panthers v Indianapolis Greyhounds | L | 38-44 |
| NCAAF | 2022/09/17 17:00 | Ohio Dominican Panthers v William Jewell College Cardinals | W | 31-21 |
| NCAAF | 2022/11/12 17:00 | Lake Erie v Northern Michigan Wildcats | L | 11-33 |
| NCAAF | 2022/11/05 20:00 | Lake Erie v Ashland Eagles | L | 23-31 |
| NCAAF | 2022/10/29 16:00 | Findlay Oilers v Lake Erie | L | 42-17 |
| NCAAF | 2022/10/22 18:00 | Lake Erie v Northwood Timberwolves | W | 21-18 |
| NCAAF | 2022/10/15 16:00 | Walsh U. Cavaliers v Lake Erie | W | 15-22 |
| NCAAF | 2022/10/08 16:00 | Lake Erie v Ohio Dominican Panthers | L | 7-38 |
| NCAAF | 2022/10/01 20:00 | Tiffin Dragons v Lake Erie | L | 52-27 |
| NCAAF | 2022/09/24 18:00 | Southwest Baptist University Bearcats v Lake Erie | L | 52-31 |