Stadium: Growney Stadium Round: 1
| NCAAF | 2022/11/12 18:00 | St John Fisher Cardinals v Utica Pioneers | L | 21-35 |
| NCAAF | 2022/11/05 17:00 | Cortland Red Dragons v St John Fisher Cardinals | L | 56-14 |
| NCAAF | 2022/10/29 18:00 | St John Fisher Cardinals v Hartwick Hawks | W | 44-26 |
| NCAAF | 2022/10/15 17:00 | Alfred Saxons v St John Fisher Cardinals | W | 7-21 |
| NCAAF | 2022/10/08 17:00 | St John Fisher Cardinals v Morrisville State Mustangs | L | 3-10 |
| NCAAF | 2022/10/01 22:00 | Brockport Golden Eagles v St John Fisher Cardinals | L | 25-0 |
| NCAAF | 2022/09/24 20:00 | St John Fisher Cardinals v Rpi Engineers | W | 3-0 |
| NCAAF | 2022/09/17 17:00 | Hobart Statesmen v St John Fisher Cardinals | L | 17-0 |
| NCAAF | 2022/11/12 17:00 | Wilkes Colonels v Kings Monarchs | W | 58-42 |
| NCAAF | 2022/11/05 16:00 | Stevenson Mustangs v Wilkes Colonels | L | 28-0 |
| NCAAF | 2022/10/29 16:00 | Wilkes Colonels v Lycoming Warriors | W | 24-7 |
| NCAAF | 2022/10/22 17:00 | Delaware Valley Aggies v Wilkes Colonels | L | 27-14 |
| NCAAF | 2022/10/15 16:00 | Wilkes Colonels v Misericordia Cougars | W | 28-0 |
| NCAAF | 2022/10/08 16:00 | Alvernia Golden Wolves v Wilkes Colonels | W | 14-35 |
| NCAAF | 2022/10/01 16:00 | Wilkes Colonels v Albright Lions | W | 27-0 |
| NCAAF | 2022/09/24 17:00 | Lebanon Valley Flying Dutchmen v Wilkes Colonels | L | 24-19 |