Stadium: Callaway Stadium Round: 1
| NCAAF | 2022/09/30 17:00 | Nc Wesleyan Battling Bishops v Lagrange Panthers | L | 37-22 |
| NCAAF | 2021/09/25 17:00 | Lagrange Panthers v Nc Wesleyan Battling Bishops | L | 21-26 |
| NCAAF | 2019/10/05 17:00 | Lagrange Panthers v Nc Wesleyan Battling Bishops | L | 35-52 |
| NCAAF | 2022/11/12 19:00 | Huntingdon Hawks v Lagrange Panthers | L | 55-7 |
| NCAAF | 2022/11/05 17:00 | Lagrange Panthers v Southern Virginia Knights | L | 21-35 |
| NCAAF | 2022/10/29 00:00 | Belhaven Blazers v Lagrange Panthers | L | 70-16 |
| NCAAF | 2022/10/22 19:00 | Brevard Tornados v Lagrange Panthers | L | 24-10 |
| NCAAF | 2022/10/08 17:00 | Lagrange Panthers v Maryville Scots | L | 17-56 |
| NCAAF | 2022/09/30 17:00 | Nc Wesleyan Battling Bishops v Lagrange Panthers | L | 37-22 |
| NCAAF | 2022/09/24 17:00 | Lagrange Panthers v Methodist Monarchs | L | 28-38 |
| NCAAF | 2022/09/17 17:00 | Lagrange Panthers v Ferrum Panthers | W | 44-38 |
| NCAAF | 2022/11/12 18:00 | Greensboro v Nc Wesleyan Battling Bishops | W | 14-35 |
| NCAAF | 2022/11/05 16:00 | Nc Wesleyan Battling Bishops v Huntingdon Hawks | L | 17-34 |
| NCAAF | 2022/10/22 17:00 | Maryville Scots v Nc Wesleyan Battling Bishops | L | 61-7 |
| NCAAF | 2022/10/15 22:00 | Nc Wesleyan Battling Bishops v Methodist Monarchs | L | 33-34 |
| NCAAF | 2022/10/08 17:00 | Belhaven Blazers v Nc Wesleyan Battling Bishops | L | 24-0 |
| NCAAF | 2022/09/30 17:00 | Nc Wesleyan Battling Bishops v Lagrange Panthers | W | 37-22 |
| NCAAF | 2022/09/24 17:00 | Southern Virginia Knights v Nc Wesleyan Battling Bishops | W | 13-14 |
| NCAAF | 2022/09/17 16:00 | Nc Wesleyan Battling Bishops v Bridgewater Eagles | L | 7-48 |