[2] Roger Federer 6-4,7-6 Kei Nishikori [12] 2018-09-20 09:50
Stadium: Centre Court Round: 27 Ground: Hardcourt outdoor
Head to Head
| Australian Open 2017 | 2017/01/22 08:00 | Roger Federer v Kei Nishikori | 6-7,6-4,6-1,4-6,6-3 |
| ATP Halle | 2014/06/14 13:30 | Kei Nishikori v Roger Federer | 3-6,6-7 |
| ATP Miami | 2014/03/27 01:25 | Roger Federer v Kei Nishikori | 6-3,5-7,4-6 |
Home History
| US Open | 2018/09/04 01:00 | John Millman v Roger Federer | 3-6,7-5,7-6,7-6 |
| US Open | 2018/09/01 18:05 | Nick Kyrgios v Roger Federer | 4-6,1-6,5-7 |
| US Open | 2018/08/30 18:45 | Benoit Paire v Roger Federer | 5-7,4-6,4-6 |
| US Open | 2018/08/28 23:00 | Yoshihito Nishioka v Roger Federer | 2-6,2-6,4-6 |
| ATP Cincinnati | 2018/08/19 20:25 | Novak Djokovic v Roger Federer | 6-4,6-4 |
| ATP Cincinnati | 2018/08/18 01:05 | Stan Wawrinka v Roger Federer | 7-6,6-7,2-6 |
| ATP Cincinnati | 2018/08/17 18:00 | Leonardo Mayer v Roger Federer | 1-6,6-7 |
| ATP Cincinnati | 2018/08/14 23:00 | Peter Gojowczyk v Roger Federer | 4-6,4-6 |
Away History
| ATP Metz | 2018/09/19 13:45 | Kei Nishikori v Peter Gojowczyk | 7-6,6-3 |
| US Open | 2018/09/07 22:50 | Kei Nishikori v Novak Djokovic | 3-6,4-6,2-6 |
| US Open | 2018/09/05 17:20 | Marin Cilic v Kei Nishikori | 6-2,4-6,6-7,6-4,4-6 |
| US Open | 2018/09/03 15:00 | Kei Nishikori v Philipp Kohlschreiber | 6-3,6-2,7-5 |
| US Open | 2018/09/01 21:00 | Diego Schwartzman v Kei Nishikori | 4-6,4-6,7-5,1-6 |
| US Open | 2018/08/28 22:35 | Maximilian Marterer v Kei Nishikori | 2-6,2-6,3-6 |
| ATP Cincinnati | 2018/08/16 00:50 | Kei Nishikori v Stan Wawrinka | 4-6,4-6 |
| ATP Cincinnati | 2018/08/13 15:00 | Kei Nishikori v Andrey Rublev | 7-5,6-3 |