[4] Sale Sharks 41-13 Atletica Castello U20 [6] 2021-01-11 01:00
Stadium: The AJ Bell Stadium Round: 14
Referee: Craig Maxwell-Keys Home Manager: Paul Deacon Away Manager: Declan Kidney
Head to Head
| Prem Rugby | 2020/12/06 14:30 | London Irish v Sale Sharks | W | 13-21 |
| Prem Rugby | 2020/03/06 20:00 | Sale Sharks v London Irish | W | 39-0 |
| Prem Rugby | 2019/10/26 14:00 | London Irish v Sale Sharks | W | 7-41 |
| Premier Rugby Cup | 2019/10/12 14:00 | London Irish v Sale Sharks | W | 22-27 |
| Prem Rugby | 2018/02/10 15:00 | London Irish v Sale Sharks | W | 9-13 |
| Prem Rugby | 2017/09/15 19:00 | Sale Sharks v London Irish | W | 36-7 |
| Prem Rugby | 2016/04/02 14:00 | London Irish v Sale Sharks | W | 15-30 |
| Prem Rugby | 2016/01/30 14:30 | Sale Sharks v London Irish | W | 38-10 |
| Prem Rugby | 2015/04/12 14:00 | London Irish v Sale Sharks | L | 25-23 |
| Prem Rugby | 2014/11/15 12:00 | Sale Sharks v London Irish | W | 36-8 |