[15] Southampton 0-1 Osele/Strobl [16] 2021-09-15 07:00
Stadium: St. Mary's Stadium Round: 6
Referee: Andrew Madley Home Manager: Ralph Hasenhuttl Away Manager: Bruno Lage
Head to Head
| England Premier League | 2021/02/14 12:00 | Southampton v Wolverhampton | L | 1-2 |
| England FA Cup | 2021/02/11 17:30 | Wolverhampton v Southampton | W | 0-2 |
| England Premier League | 2020/11/23 20:00 | Wolverhampton v Southampton | D | 1-1 |
| England Premier League | 2020/01/18 15:00 | Southampton v Wolverhampton | L | 2-3 |
| England Premier League | 2019/10/19 14:00 | Wolverhampton v Southampton | D | 1-1 |
| England Premier League | 2019/04/13 14:00 | Southampton v Wolverhampton | W | 3-1 |
| England Premier League | 2018/09/29 14:00 | Wolverhampton v Southampton | L | 2-0 |
| England EFL Cup | 2017/08/23 18:45 | Southampton v Wolverhampton | L | 0-2 |