| 1 | 2 | H | 3 | 4 | F |
|---|---|---|---|---|---|
| 0 | 17 | 17 | 10 | 7 | 34 |
| 7 | 0 | 7 | 10 | 7 | 24 |
Lineups
| BUF Bills | SF 49ers |
| Lineup | |
|---|---|
| 39 - DB - Levi Wallace | Charlie Woerner - TE - 89 |
| 41 - TE - Reggie Gilliam | Kentavius Street - DE - 95 |
| 9 - Left back - Andre Smith | Mike McGlinchey - OL - 69 |
| 33 - Center back - Siran Neal | Kai Nacua - DB - 43 |
| 46 - DB - Jaquan Johnson | Kendrick Bourne - WR - 84 |
| 71 - OL - Ryan Bates | Daniel Brunskill - TE - 60 |
| 21 - Center back - Jordan Poyer | Nick Mullens - QB - 4 |
| 91 - DT - Ed Oliver | D.J. Jones - DT - 93 |
| 2 - K - Tyler Bass | C.J. Beathard - QB - 3 |
| 13 - WR - Gabriel Davis | Jordan Willis - DE - 94 |
| 63 - OL - Brian Winters | Ahkello Witherspoon - DB - 23 |
| 57 - DE - A.J. Epenesa | Taybor Pepper - LS - 46 |
| - WR - Cole Beasley | Joe Walker - Left back - 59 |
| 20 - Right back - Zack Moss | Justin Skule - OL - 67 |
| 5 - QB - Matt Barkley | Raheem Mostert - Right back - 31 |
| 25 - Right back - Taiwan Jones | Demetrius Flannigan-Fowles - SAF - 45 |
| 55 - DE - Jerry Hughes | Fred Warner - Left back - 54 |
| - OL - Ike Boettger | Tarvarius Moore - DB - 33 |
| 88 - TE - Dawson Knox | Colton McKivitz - OL - 68 |
| 49 - Left back - Tremaine Edmunds | Javon Kinlaw - DT - 99 |
| 23 - Center back - Micah Hyde | Dre Greenlaw - Left back - 57 |
| 17 - QB - Josh Allen | Jeffery Wilson - Right back - 30 |
| 77 - OT - Ty Nsekhe | River Cracraft - WR - 86 |
| 60 - OL - Mitch Morse | Tim Harris - Center back - 35 |
| 73 - OL - Dion Dawkins | Mitch Wishnowsky - Pivot - 18 |
| 27 - Center back - Tre'Davious White | Kevin Givens - DT - 90 |
| 76 - OL - Jon Feliciano | Deebo Samuel - WR - 19 |
| 61 - DT - Justin Zimmer | Marcell Harris - DB - 36 |
| 90 - DL - Quinton Jefferson | Brandon Aiyuk - WR - 11 |
| 69 - LS - Reid Ferguson | Richie James - WR - 13 |
| 44 - Left back - Tyler Matakevich | Ross Dwelley - TE - 82 |
| 14 - WR - Stefon Diggs | Azeez Al-Shaair - Left back - 51 |
| 31 - SAF - Dean Marlowe | Jason Verrett - Center back - 2 |
| 58 - Left back - Matt Milano | Arik Armstead - DL - 91 |
| 19 - WR - Isaiah McKenzie | Dion Jordan - DE - 96 |
| 54 - Left back - A.J. Klein | Tevin Coleman - Right back - 26 |
| 9 - Pivot - Corey Bojorquez | Hroniss Grasu - OL - 50 |
| 85 - TE - Lee Smith | Jerick McKinnon - QB - 28 |
| 26 - Right back - Devin Singletary | Jordan Reed - TE - 81 |
| 75 - T - Daryl Williams | Kyle Juszczyk - FB - 44 |
| 92 - DE - Darryl Johnson | Robbie Gould - K - 9 |
| 18 - WR - Andre Roberts | Trent Williams - OL - 71 |
| 97 - DE - Mario Addison | Tom Compton - OL - 66 |
| 94 - DT - Vernon Butler | Richard Sherman - Center back - 25 |
| 29 - Center back - Josh Norman | Jimmie Ward - SAF - 1 |
| 7 - Center back - Taron Johnson | Dontae Johnson - Center back - 27 |
| 99 - DT - Harrison Phillips | Laken Tomlinson - OG - 75 |
| 87 - WR - Jake Kumerow | Kerry Hyder - DL - 92 |
| Substitutes | |
Events
- 1st Drive - First Down - Yes #BUF Bills #Q1#9'#355#15
- 1st Drive - Turnover #BUF Bills #Q1#9'#355#15
- 2nd Drive - First Down - Yes #SF 49ers #Q1#1'#807#15
- 2nd Drive - Turnover #SF 49ers #Q1#1'#807#15
- 3rd Drive - First Down - No #BUF Bills #Q1#1'#815#15
- 3rd Drive - Turnover #BUF Bills #Q1#1'#815#15
- 1st Score - Touchdown - Aiyuk #SF 49ers #Q1#0'#859#15
- 1st Quarter Race to 6 - #SF 49ers #Q1#0'#859#15
- 4th Drive - First Down - Yes #SF 49ers #Q1#0'#859#15
- 4th Drive - Offensive Touch Down - #SF 49ers #Q1#0'#859#15
- 1 PAT - #SF 49ers #Q1#0'#859#15
- Score After 1st Quarter - 0-7
- 2nd Score - Touchdown - Beasley #BUF Bills #Q2#13'#119#15
- 2nd Quarter Race to 6 - #BUF Bills #Q2#13'#119#15
- 5th Drive - First Down - Yes #BUF Bills #Q2#13'#119#15
- 5th Drive - Offensive Touch Down - #BUF Bills #Q2#13'#119#15
- 1 PAT - #BUF Bills #Q2#13'#119#15
- 6th Drive - First Down - Yes #SF 49ers #Q2#10'#275#15
- 6th Drive - Punt #SF 49ers #Q2#10'#275#15
- 3rd Score - Touchdown - Knox #BUF Bills #Q2#2'#747#15
- 2nd Quarter Race to 12 - #BUF Bills #Q2#2'#747#15
- Race to 10 - #BUF Bills #Q2#2'#747#15
- 7th Drive - First Down - Yes #BUF Bills #Q2#2'#747#15
- 7th Drive - Offensive Touch Down - #BUF Bills #Q2#2'#747#15
- 1 PAT - #BUF Bills #Q2#2'#747#15
- 8th Drive - First Down - Yes #SF 49ers #Q2#0'#842#15
- 8th Drive - Punt #SF 49ers #Q2#0'#842#15
- 9th Drive - First Down - Yes #BUF Bills #Q2#0'#900#15
- 9th Drive - Field Goal Attempt #BUF Bills #Q2#0'#900#15
- 4th Score - Field Goal - #BUF Bills #Q2#0'#900#15
- Race to 15 - #BUF Bills #Q2#0'#900#15
- Score After 2nd Quarter - 17-7
- 10th Drive - First Down - Yes #SF 49ers #Q3#11'#231#15
- 10th Drive - Field Goal Attempt #SF 49ers #Q3#11'#231#15
- 5th Score - Field Goal - #SF 49ers #Q3#11'#231#15
- 6th Score - Touchdown - McKenzie #BUF Bills #Q3#5'#555#15
- 3rd Quarter Race to 6 - #BUF Bills #Q3#5'#555#15
- Race to 20 - #BUF Bills #Q3#5'#555#15
- 11th Drive - First Down - Yes #BUF Bills #Q3#5'#555#15
- 11th Drive - Offensive Touch Down - #BUF Bills #Q3#5'#555#15
- 1 PAT - #BUF Bills #Q3#5'#555#15
- 12th Drive - First Down - No #SF 49ers #Q3#5'#579#15
- 12th Drive - Turnover #SF 49ers #Q3#5'#579#15
- 13th Drive - First Down - No #BUF Bills #Q3#2'#721#15
- 13th Drive - Field Goal Attempt #BUF Bills #Q3#2'#721#15
- 7th Score - Field Goal - #BUF Bills #Q3#2'#721#15
- 3rd Quarter Race to 9 - #BUF Bills #Q3#2'#721#15
- Race to 25 - #BUF Bills #Q3#2'#721#15
- 8th Score - Touchdown - Juszczyk #SF 49ers #Q3#0'#879#15
- 14th Drive - First Down - Yes #SF 49ers #Q3#0'#879#15
- 14th Drive - Offensive Touch Down - #SF 49ers #Q3#0'#879#15
- 1 PAT - #SF 49ers #Q3#0'#879#15
- Score After 3rd Quarter - 27-17
- 9th Score - Touchdown - Davis #BUF Bills #Q4#9'#325#15
- 4th Quarter Race to 6 - #BUF Bills #Q4#9'#325#15
- Race to 30 - #BUF Bills #Q4#9'#325#15
- 15th Drive - First Down - Yes #BUF Bills #Q4#9'#325#15
- 15th Drive - Offensive Touch Down - #BUF Bills #Q4#9'#325#15
- 1 PAT - #BUF Bills #Q4#9'#325#15
- 16th Drive - First Down - Yes #SF 49ers #Q4#6'#487#15
- 16th Drive - Turnover #SF 49ers #Q4#6'#487#15
- 17th Drive - First Down - Yes #BUF Bills #Q4#4'#658#15
- 17th Drive - Punt #BUF Bills #Q4#4'#658#15
- 10th Score - Touchdown - Reed #SF 49ers #Q4#2'#733#15
- 18th Drive - First Down - Yes #SF 49ers #Q4#2'#733#15
- 18th Drive - Offensive Touch Down - #SF 49ers #Q4#2'#733#15
- 1 PAT - #SF 49ers #Q4#2'#733#15