Stadium: State Farm Stadium Round: 1
Home Manager: Brandon Staley Away Manager: Kliff Kingsbury
| 1 | 2 | H | 3 | 4 | F |
|---|---|---|---|---|---|
| 0 | 14 | 14 | 3 | 8 | 25 |
| 7 | 10 | 17 | 0 | 7 | 24 |
| LA Chargers | ARZ Cardinals |
| Lineup | |
|---|---|
| 26 - Center back - Asante Samuel Jr. | Zaven Collins - Left back - 25 |
| 59 - OLB - Derrek Tuszka | Lecitus Smith - OL - 54 |
| 10 - QB - Justin Herbert | Ezekiel Turner - DB - 47 |
| 25 - Right back - Joshua Kelley | Rashaad Coward - OT - 65 |
| 32 - SAF - Alohi Gilman | Billy Price - OL - 53 |
| 9 - Left back - Kenneth Murray Jr. | Cody Ford - OL - 72 |
| 47 - - Josh Harris | Trayvon Mullen - Center back - 21 |
| 31 - Left back - Nick Niemann | Kyler Murray - QB - 1 |
| 40 - Right back - Zander Horvath | Trysten Hill - DL - 98 |
| 36 - DB - Ja'Sir Taylor | Jonathan Ledbetter - DE - 93 |
| 68 - OL - Jamaree Salyer | Christian Matthew - Center back - 35 |
| 83 - WR - Michael Bandy | Corey Clement - Right back - 23 |
| 88 - TE - Tre McKitty | Sean Harlow - OL - 64 |
| 73 - OT - Foster Sarell | Ben Niemann - Left back - 56 |
| 96 - NT - Breiden Fehoko | Zach Allen - DE - 94 |
| 5 - WR - Josh Palmer | Jalen Thompson - SAF - 34 |
| 57 - Left back - Amen Ogbongbemiga | Marco Wilson - Center back - 20 |
| 94 - DE - Chris Rumph | Josh Jones - OL - 79 |
| 33 - DB - Deane Leonard | Leki Fotu - DT - 95 |
| 64 - OT - Brenden Jaimes | Isaiah Simmons - ILB - 9 |
| 79 - OT - Trey Pipkins III | Myjai Sanders - DE - 41 |
| 28 - Right back - Isaiah Spiller | Cameron Thomas - DE - 97 |
| 69 - DL - Sebastian Joseph-Day | Dennis Gardeck - OLB - 45 |
| 23 - Center back - Bryce Callahan | Trey McBride - TE - 85 |
| 52 - Left back - Khalil Mack | Keaontay Ingram - Right back - 30 |
| 63 - Center - Corey Linsley | Marquise Brown - WR - 2 |
| 3 - DB - Derwin James Jr. | Victor Dimukeje - DE - 52 |
| 76 - Center - Will Clapp | Andre Baccellia - WR - 82 |
| 56 - DE - Morgan Fox | Tanner Vallejo - Left back - 51 |
| 49 - Left back - Drue Tranquill | James Conner - Right back - 6 |
| 1 - WR - DeAndre Carter | Maxx Williams - TE - 87 |
| 30 - Right back - Austin Ekeler | Pharoh Cooper - WR - 15 |
| 43 - DB - Michael Davis | Chris Banjo - DB - 31 |
| 90 - DL - Tyeler Davison | Max Garcia - OL - 75 |
| 42 - Left back - Troy Reeder | Matt Prater - K - 5 |
| 71 - OG - Matt Feiler | A.J. Green - WR - 18 |
| 82 - WR - Richard Rodgers | DeAndre Hopkins - WR - 10 |
| 16 - Pivot - J.K. Scott | Markus Golden - DL - 44 |
| 13 - WR - Keenan Allen | Andy Lee - Pivot - 14 |
| 22 - SAF - J.T. Woods | Kelvin Beachum - OT - 68 |
| 11 - K - Cameron Dicker | Stephen Anderson - TE - 89 |
| 8 - Left back - Kyle Van Noy | Budda Baker - DB - 3 |
| 92 - DL - Joe Gaziano | Aaron Brewer - LS - 46 |
| 41 - DB - Raheem Layne | Antonio Hamilton - Center back - 33 |
| 77 - Guard - Zion Johnson | Robby Chosen - WR - 81 |
| 48 - TE - Stone Smartt | J.J. Watt - DL - 99 |
| 7 - TE - Gerald Everett | Kamu Grugier-Hill - Left back - 57 |
| Substitutes | |