Stadium: Highmark Stadium Round: 17
Home Manager: Nick Sirianni Away Manager: Sean McDermott
| 1 | 2 | H | 3 | 4 | F |
|---|---|---|---|---|---|
| 7 | 6 | 13 | 0 | 0 | 13 |
| 0 | 0 | 0 | 0 | 12 | 12 |
| PHI Eagles | BUF Bills |
| Lineup | |
|---|---|
| 83 - TE - Kylen Granson | Deone Walker - DT - 96 |
| 30 - Left back - Jihaad Campbell | Javon Solomon - Left back - 56 |
| 11 - WR - A.J. Brown | Dorian Williams - Left back - 42 |
| 33 - DB - Cooper DeJean | Ray Davis - Right back - 22 |
| 80 - WR - Darius Cooper | Christian Benford - DB - 47 |
| 7 - DB - Kelee Ringo | Joe Andreessen - Left back - 44 |
| 49 - DB - Brandon Johnson | David Edwards - OL - 76 |
| 10 - Pivot - Braden Mann | Khalil Shakir - WR - 10 |
| 4 - K - Jake Elliott | Alec Anderson - OT - 70 |
| 8 - ATH - Adoree Jackson | James Cook - Right back - 4 |
| 42 - Left back - Smael Mondon | Phidarian Mathis - DL - 72 |
| 32 - SAF - Reed Blankenship | Terrel Bernard - Left back - 8 |
| 50 - Left back - Jaelan Phillips | Ryan Van Demark - OL - 74 |
| 47 - LS - Charley Hughlett | O'Cyrus Torrence - Guard - 64 |
| 69 - Center - Landon Dickerson | Connor McGovern - OL - 66 |
| 90 - DT - Jordan Davis | Spencer Brown - OT - 79 |
| 55 - DE - Brandon Graham | Josh Palmer - WR - 5 |
| 28 - Right back - Will Shipley | Gregory Rousseau - DE - 50 |
| 54 - Left back - Jeremiah Trotter | Jordan Hancock - DB - 37 |
| 81 - TE - Grant Calcaterra | T.J. Sanders - DL - 98 |
| 88 - TE - Dallas Goedert | Maxwell Hairston - DB - 31 |
| 1 - QB - Jalen Hurts | Cole Bishop - SAF - 24 |
| 36 - TE - Cameron Latu | Keleki Latu - TE - 83 |
| 97 - DT - Moro Ojomo | Sedrick Van Pran-Granger - OL - 62 |
| 39 - SS - Marcus Epps | Gabriel Davis - WR - 13 |
| 95 - DT - Ty Robinson | A.J. Epenesa - DE - 57 |
| 3 - Left back - Nolan Smith | Jackson Hawes - TE - 85 |
| 2 - WR - Jahan Dotson | Tyrell Shavers - WR - 14 |
| 21 - SAF - Sydney Brown | Brandin Cooks - WR - 18 |
| 74 - OL - Fred Johnson | Michael Badgley - K - 32 |
| 79 - OG - Matt Pryor | Josh Allen - QB - 17 |
| 68 - OT - Jordan Mailata | Matt Milano - Left back - 58 |
| 51 - OL - Cameron Jurgens | Sam Franklin - Left back - 28 |
| 58 - DL - Jalyx Hunt | Cam Lewis - Center back - 39 |
| 53 - OLB - Zack Baun | Taron Johnson - Center back - 7 |
| 37 - Right back - Tank Bigsby | Andre Jones Jr. - Left back - 75 |
| 98 - DT - Jalen Carter | Larry Ogunjobi - DL - 99 |
| 27 - Center back - Quinyon Mitchell | Dion Dawkins - OL - 73 |
| 23 - DB - Jakorian Bennett | Tre'Davious White - Center back - 27 |
| 64 - OT - Brett Toth | Reid Ferguson - LS - 69 |
| 56 - OL - Tyler Steen | Joey Bosa - DL - 97 |
| 94 - DL - Byron Young | Reggie Gilliam - TE - 41 |
| 6 - WR - DeVonta Smith | Shaq Thompson - Left back - 45 |
| 18 - WR - Britain Covey | Darnell Savage - DB - 25 |
| 26 - Right back - Saquon Barkley | Ty Johnson - Right back - 26 |
| Substitutes | |