Stadium: State Farm Stadium Round: 11
Home Manager: Kyle Shanahan Away Manager: Jonathan Gannon
| 1 | 2 | H | 3 | 4 | F |
|---|---|---|---|---|---|
| 13 | 12 | 25 | 10 | 6 | 41 |
| 7 | 3 | 10 | 0 | 12 | 22 |
| SF 49ers | ARZ Cardinals |
| Lineup | |
|---|---|
| 36 - SAF - Marques Sigle | Walter Nolen - DT - 97 |
| 28 - Center back - Darrell Luter Jr. | Elijah Higgins - WR - 84 |
| 2 - DB - Deommodore Lenoir | Jared Bartlett - Left back - 48 |
| 6 - DB - Malik Mustapha | Owen Pappoe - Left back - 44 |
| 44 - FB - Kyle Juszczyk | Garrett Williams - Center back - 21 |
| 64 - OL - Jake Brendel | Zonovan Knight - Right back - 20 |
| 27 - SAF - Ji'Ayir Brown | Emari Demercado - Right back - 31 |
| 77 - OL - Dominick Puni | Chad Ryland - K - 38 |
| 25 - Center back - Jason Pinnock | Trey McBride - TE - 85 |
| 61 - OL - Matt Hennessy | Michael Wilson - WR - 14 |
| 68 - OL - Colton McKivitz | Jon Gaines II - OL - 71 |
| 45 - Left back - Nickolas Martin | P.J. Mustipher - DT - 79 |
| 7 - K - Thomas Morstead | Dante Stills - DL - 55 |
| 20 - DB - Upton Stout | Xavier Thomas - DL - 54 |
| 95 - DT - Alfred Collins | Elijah Jones - DB - 28 |
| 99 - DT - CJ West | Darius Robinson - DL - 56 |
| 78 - OL - Ben Bartch | Kei'Trel Clark - Center back - 13 |
| 71 - OL - Trent Williams | Isaiah Adams - OL - 74 |
| 62 - OL - Austen Pleasants | Zaven Collins - Left back - 25 |
| 92 - DT - Jordan Elliott | Michael Carter - Right back - 22 |
| 46 - LS - Jon Weeks | Darren Hall - Center back - 30 |
| 5 - WR - Demarcus Robinson | Denzel Burke - Center back - 29 |
| 85 - TE - George Kittle | Akeem Davis-Gaither - Left back - 27 |
| 93 - DL - Kalia Davis | Josiah Deguara - TE - 45 |
| 89 - TE - Luke Farrell | Jordan Burch - DE - 52 |
| 18 - K - Eddy Pineiro | BJ Ojulari - OLB - 9 |
| 15 - WR - Jauan Jennings | Max Melton - DB - 16 |
| 31 - Right back - Isaac Guerendo | Paris Johnson Jr. - OL - 70 |
| 13 - QB - Brock Purdy | Cody Simon - Left back - 50 |
| 26 - DB - Chase Lucas | Josh Fryar - OL - 78 |
| 51 - Left back - Robert Beal Jr. | Kitan Crawford - SAF - 36 |
| 57 - Left back - Luke Gifford | Xavier Weaver - WR - 89 |
| 3 - Right back - Brian Robinson | Josh Sweat - DE - 10 |
| 10 - QB - Mac Jones | Budda Baker - DB - 3 |
| 47 - Left back - Bryce Huff | Dalvin Tomlinson - DL - 94 |
| 23 - Right back - Christian McCaffrey | Jacoby Brissett - QB - 7 |
| 84 - WR - Kendrick Bourne | Pharaoh Brown - TE - 49 |
| 9 - WR - Skyy Moore | Evan Brown - OL - 63 |
| 91 - DT - Sam Okuayinonu | Will Hernandez - OL - 76 |
| 48 - Left back - Tatum Bethune | Greg Dortch - WR - 4 |
| 88 - TE - Jake Tonges | Hjalte Froholdt - OL - 72 |
| 33 - Center back - Siran Neal | Jalen Thompson - SAF - 34 |
| 1 - WR - Ricky Pearsall | Calais Campbell - DE - 93 |
| 53 - Left back - Dee Winters | Kelvin Beachum - OT - 68 |
| 59 - OLB - Curtis Robinson | Andre Baccellia - WR - 82 |
| - DB - Renardo Green | Aaron Brewer - LS - 46 |
| 74 - OL - Spencer Burford | Pat O'Donnell - Pivot - 39 |
| 56 - DL - Keion White | - |
| Substitutes | |