Louisville 23-54 Syracuse 2018-08-27 20:00
Stadium: JMA Wireless Dome Round: 1
Home Manager: Bobby Petrino Away Manager: Dino Babers
Head to Head
| NCAAF | 2017/11/18 20:30 | Syracuse v Louisville | W | 10-56 |
| NCAAF | 2016/09/10 00:00 | Louisville v Syracuse | W | 62-28 |
| NCAAF | 2015/11/07 17:30 | Louisville v Syracuse | W | 41-17 |
| NCAAF | 2014/10/03 23:00 | Syracuse v Louisville | W | 6-28 |
| NCAAF | 2012/11/10 12:00 | Syracuse v Louisville | L | 45-26 |
| NCAAF | 2011/10/29 12:00 | Louisville v Syracuse | W | 27-10 |
| NCAAF | 2010/11/06 12:00 | Syracuse v Louisville | W | 20-28 |
| NCAAF | 2009/11/14 12:00 | Louisville v Syracuse | W | 10-9 |
Home History
| NCAAF | 2017/12/30 17:00 | Louisville v Mississippi State | L | 27-31 |
| NCAAF | 2017/11/25 17:00 | Louisville v Kentucky | W | 44-17 |
| NCAAF | 2017/11/18 20:30 | Syracuse v Louisville | W | 10-56 |
| NCAAF | 2017/11/11 20:30 | Virginia v Louisville | W | 21-38 |
| NCAAF | 2017/10/28 16:20 | Louisville v Wake Forest | L | 32-42 |
| NCAAF | 2017/10/21 16:00 | Florida State v Louisville | W | 28-31 |
| NCAAF | 2017/10/21 16:00 | Louisville v Florida State | W | 31-28 |
| NCAAF | 2017/10/14 16:20 | Boston College v Louisville | L | 45-42 |
Away History
| NCAAF | 2017/11/25 17:20 | Boston College v Syracuse | L | 42-14 |
| NCAAF | 2017/11/18 20:30 | Syracuse v Louisville | L | 10-56 |
| NCAAF | 2017/11/11 20:00 | Wake Forest v Syracuse | L | 64-43 |
| NCAAF | 2017/11/04 16:20 | Syracuse v Florida State | L | 24-27 |
| NCAAF | 2017/10/21 21:30 | Miami Florida v Syracuse | L | 27-19 |
| NCAAF | 2017/10/21 19:30 | Syracuse v Miami Florida | L | 19-27 |
| NCAAF | 2017/10/13 23:00 | Clemson v Syracuse | W | 24-27 |
| NCAAF | 2017/10/07 16:30 | Pittsburgh v Syracuse | W | 24-27 |